Show simple item record

dc.contributor.authorMuhtadi
dc.contributor.authorWahyuningtyas, Nurcahyanti
dc.contributor.authorSutrisna, EM
dc.contributor.authorSuhendi, Andi
dc.contributor.authorPermatasari, Zuvita Dwi
dc.date.accessioned2016-02-24T03:31:51Z
dc.date.available2016-02-24T03:31:51Z
dc.date.issued2016-02
dc.identifier.citationBrest, N, A., Heider, C., Mehbod, H., and Onesti, G., 1966, Drug Control of Diuretic-Induced Hyperurisemia, JAMA, 195 (1), 132-134. Dipiro, J.T., Robert, L.T., Gary, C.Y., Gary, R.M., Barbara, G.W., Michael, P.L.,2008, Pharmacotherapy : A Pathophysiologic Approach Seven Edition, Mc Graw Hill Medical, New York. Edwards, N. L., 2008, The Role of Hyperuricemic and Goud in Kidney and Cardiovascular Disease, Cleveland Clinic Journal of Medicine, 75 (5), S13- S16. Haidari, F., Keshavarz, S. A., Rashidi, M. R and Shahi, M. M., 2009, Orange Juice and Hesperetin Supplementation to Hyperuricemic Rats Alter Oxidative Stress Markers and Xanthine Oxidoreductase Activity, J. Clin. Biochem. Nutr., 45 (3), 285-291. Hidayat, R., 2009, Gout dan Hiperurisemia, Medicinus, Scientific Journal of Pharmaceutical Development and Medical Aplication, 22 (2). Mangunwardoyo, W., Cahyaningsih, E dan Usia, T., 2008, Uji Aktivitas Antimikroba Ekstrak Herba Meniran ( Phyllanthus niruri L.), Jurnal Obat Bahan Alam, Vol 7 (1), 54-61. Murugaiyah, L., 2008, Phytochemical, Pharmacological and Pharmakokinetic Studies of Phyllanthus niruri Linn. Lignan As Potential Antihyperuricemic Agents, Thesis, Universiti Sains Malaysia. Muhtadi, Sutrisna, E.M., Wahyuningtyas, N.,dan Suhendi, A., 2010, Laporan Akhir Tahun Pertama Riset Andalan Perguruan Tinggi Dan Industri (Rapid), Pengembangan Agen Fitoterapi Asam Urat dari Beberapa Tumbuhan Obat Indonesia untuk Peningkatan Kapasitas bahan Alam Obat menjadi Produk Obat Herbal Terstandar (OHT), Direktorat Jendral Pendidikan Tinggi Departemen Pendidikan Nasional, Jakarta. Mutschler, E., 1986, Dinamika Obat Buku Ajar Farmakologi dan Toksikologi, Edisi kelima, Penerbit ITB, Bandung. Nafrialdi, 2008, Diuretik dan antidiuretik, dalam : Gunawan, G.S., Setiabudy, R., Nafrialdi, Elysabeth, Farmakologi dan Terapi, edisi 5, hal 389, Balai Penerbit FKUI, Jakarta. Piexoto, Monego, Jardim, Carvalho, Sousa, Olivera, and Neto, 2001, Diet and Medication in the Treatment of Hyperuricemia in Hypertensive Patients, Arq Bras Cardiol, Volume 76 (6), 468-572. Samali, A., Florence, D. T., Odeniran, O. A. and Cordelia O.N., 2011, Evaluation of chemical constituents of Phyllanthus Niruri, African Journal of Pharmacy and Pharmacology Vol. 6(3), pp. 125-128. Schlesinger, N., 2005, Dietary Factors and Hyperuricaemia, Current Pharmaceutical Design, Vol. 11, No. 32, 4133-4138. Spieker L.E., Ruschitzka F.T., Luscher T.F., Noll G., 2002, The management of hyperuricemia and gout in patients with heart failure, The European Journal of Heart Failure ,Vol 4, 403–410. Sudoyo, A.W., Setiyohadi, B., Alwi, I., Simadibrata, M dan Setiadi, S., 2007, Ilmu Penyakit Dalam, Pusat Penerbitan Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia, Jakarta. Tinahones, J.F., Perres-Lindon, G., Sorigeur, F.J., Pareja, A., Guijo, P.S., and Collantes, E., 1997, Dietary Alterations in Plasma Very Low Density Lipoprotein Levels Modify Renal Excretion of Urates in Hyperuricemic-Hypertrigliceridemic Patients, Journal of Clinical Endcrinology and Metabolism, vol. 82 (4). Udupa, A.L., Sanjeeva, Benegal, A., Prusty,V., Kodancha, G.P., Kumar, M.C.S., Bhat, V and Rantnakar, U.P., 2010, Diuretic activity of Phyllanthus niruri (Linn.) in rats, Health, Vol.2, No.5, 511-512. Venkataraman, R., Kellum, J.A., 2007, Defining Acute Renal Failure: the RIFLE criteria, Journal of Intensive Care Medicine, vol 22 (4). Viazzi, F., Leoncini, G., Ratto, E., Falqui, V., Parodi, A., Conti, N. et al., 2007, Mild Hyperuricemia and Subclinical Renal Damage in Untreated Primaryin_ID
dc.identifier.issn2407-9189
dc.identifier.urihttp://hdl.handle.net/11617/6665
dc.description.abstractMeniran (Phyllanthus niruri L) herbal extract had shown antihyperuricemia effect through uricosuric action. The purpose of this study was to determine the effect of 200 mg/kg.bw extracts in increase the urine volume of hyperuricemic mice. This study was a quasi-experimental with a complete randomized block design. Fifteen mice were divided into 3 groups. Such as, normal group was given aqua pro injection 1 mL/20 g.bw (i.p) and distilled water with 0.5 mL/20g.bw (po), negative group was given 250 mg/kg potassium oxonate (i.p) and distilled water with 5 mL/20g.bw (p.o), treatment group was given 250 mg/kg.bw potassium oxonate (i.p) and 200 mg/ kg.bw extracts of meniran (p.o). Cumulative urine volume was measured at the 0,1,2,3,4,5,6,7,8 and 24 hour for 3 days. Volume of drinking and feed were accounted for 3 days. Data was analyzed with Kruskal-Wallis and Mann Whitney Test. The result showed that in negative group the urine volume produced was higher than the normal group (p = 0.007). Meanwhile, urine volume of others group was lower than negative control (p = 0.011). Based on the data, meniran extract could not increase the urine volume in hyperuricemia mice, aside from the extract can increase the urine volume in normal mice.in_ID
dc.language.isoidin_ID
dc.publisherLPPM STIKES Muhammadiyah Kudusin_ID
dc.subjectPhyllanthus niruriin_ID
dc.subjecthyperuricemiain_ID
dc.subjecturinary volumein_ID
dc.titlePengaruh Pemberian Ekstrak Herba Meniran (Phyllanthus Niruri ) Terhadap Volume Urin Mencit Hiperurisemiain_ID
dc.typeArticlein_ID


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record