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| dc.description.abstract | This study used an experimental research design, using 10 male rats weighing 200-300 g, aged 2-3 months who were divided into 2 groups: control and treatment. Each group contains 5 rats that weight more than 200 g. Glibenclamide control group rats given a dose of 5 mg / kg orally, while for the treatment group was given glibenclamide at a dose of 5 mg / kg concomitant with black rice bran extract 200mg / kg orally. At 0; 0.5; 1; 1.5;
2; 2.5; 3; 4; 6; 8; 10; and 12 hours, blood drawn each rat of 0.5 mL through lateral tail veins of rats. Pharmacokinetic parameters for each group were tested using independent sample t test with a value of 95%. Results of this study showed that the pharmacokinetic profile glibenclamide did not change with the concurrent use between glibenclamide with
black rice bran extract (P>0,05). The primary pharmacokinetic parameters of concurrent use between glibenclamide with black rice bran extracts show the result, the value Ka =
0,630 ± 0,207 hours, Vd = 0,134 ± 0,097 L / kg and CLt = 0,052 ± 0,035 L / h. | in_ID |
