Pengaruh Pemberian Ekstrak Etanol Meniran (Phyllanthus Niruri L) Selama 90 Hari terhadap Fungsi Hati Tikus

Abstract

Preliminary research showed that meniran herbs (Phyllanthus niruri L.) had various biological activities such as anticarcinogen, hepatoprotective, antioxidant. A medicinal plant to be developed into a standardized herbal medicine, it is needed safety test in animal (preclinic test). This study aimed to evaluate the influence of ethanolic extract of meniran on liver function in rats given for the long term. A total of 36 male and female rats were divided into 3 groups: control (aquadest), ethanolic extract of meniran with dose 50 mg/kgbw and 250 mg/kgbw, each group consisted of 6 rats. Treatment was given with repeated doses for 90 days. To evaluate the liver function, there were 2 parameters: quantitative and qualitative data. The quantitative data include SGPT (serum glutamate piruvate transaminase) and SGOT (serum glutamate oxaloacetate transaminase) and qualitative data was histopathology of liver. SGPT and SGOT level were measured on days 0, and 90. SGPT and SGOT level were compared between before and after treatment using paired t test with a 95% confidence level. Data of histopathology compared to the control group. The results showed that the ethanolic extract of meniran dose 50 and 250 mg/kg body weight administered repeatedly for 90 days had no toxic effect on liver function of male and female rats.