Formulasi dan Evaluasi Mikropartikel Dexamethasone Lepas Lambat dengan Matriks Ethyl Cellulose (EC)

Abstract

Delivery of drug using microparticles (MP) can be applied in the field of tissue engineering for replacing damaged tissue. MP dexamethasone (DXM)-a corticosteroid for stimulating the growth of bone cells-could be used as a scaffold to support cell growth in three - dimensional (3D) structure and as a drug reservoir for the growth cells that can release the drug in controlled manner. Ethyl cellulose (EC) is a biodegradable polymer and has ability to control the release of drug by swelling mechanism. The purpose of this study was to perform the MP using EC and characterize of physical properties, encapsulation efficiency (EE) and the drug release from MP with various concentrations of EC and polyvinyl alcohol (PVA) as emulsifier. MP EC made by emulsification method. Particle size and shape were characterized by observation using light microscope and Scanning Electron Microscope (SEM). Efficiency of encapsulation (EE) is determined by the direct method and the drug release conducted in the medium of phosphate buffer saline +0.1 % tween 80 at 37°C. MP EC were characterized as sphere particles and the diameter increased related to increasing concentrations of EC. DXM showed high incorporation in EC and are not affected by the EC concentration as well as PVA concentration used in the manufacture of MP. Drug release from MP EC is strongly influenced by the EC and PVA concentration. The shape of MP can be maintained in the drug release medium for 28 days.