The Effect of Giving Glucomannan Porang Tuber (Amorphophallus oncophyllus Prain ex Hook. F.) on SGPT and SGOT Levels of Wistar Male Rats Blood Induced By Paracetamol

Abstract

Indonesia is a country with a high prevalence of liver disease. Liver is important for survival and plays a role in every metabolic function of the body. One of the causes of liver disorder is because of drugs. One of the drugs that cause liver damage is paracetamol. Glucomannan is a major component of the porang tuber that serves as a soluble fiber. Glucomannan is thought to have hepatotherapy effects as a potential antioxidant.. The aim of this study is to determine the effect of glucomannan porang tuber (Amorphophallus oncophyllus Prain ex Hook. F.) with graded doses of the blood levels of SGPT and SGOT wistar male rats induced by paracetamol dose of 1,638 g/kg BB. This research was experimental study. The treatment in this study was porang glucomannan with a dose of 25 mg / kg, 50 mg / kg and 100 mg / kg. The Population of the study was white male of Wistar rats aged 3-4 months with a weight of 180g - 250g, and healthy. The result of the analysis showed that glucomannan Porang (Amorphophallus oncophyllus Prain ex Hook. F.) has an effect as hepatotherapy. Giving glucomannan porang at a dose of 50 mg / kg rat has an effect to decrease blood levels of SGPT and SGOT wistar male rats induced by paracetamol.