Pengaruh Bekatul Beras Hitam (Black Rice Bran) Terhadap Profil Farmakokinetika Glibenklamid pada Tikus Galur Sprague Dawley (SD)

Abstract

This study used an experimental research design, using 10 male rats weighing 200-300 g, aged 2-3 months who were divided into 2 groups: control and treatment. Each group contains 5 rats that weight more than 200 g. Glibenclamide control group rats given a dose of 5 mg / kg orally, while for the treatment group was given glibenclamide at a dose of 5 mg / kg concomitant with black rice bran extract 200mg / kg orally. At 0; 0.5; 1; 1.5; 2; 2.5; 3; 4; 6; 8; 10; and 12 hours, blood drawn each rat of 0.5 mL through lateral tail veins of rats. Pharmacokinetic parameters for each group were tested using independent sample t test with a value of 95%. Results of this study showed that the pharmacokinetic profile glibenclamide did not change with the concurrent use between glibenclamide with black rice bran extract (P>0,05). The primary pharmacokinetic parameters of concurrent use between glibenclamide with black rice bran extracts show the result, the value Ka = 0,630 ± 0,207 hours, Vd = 0,134 ± 0,097 L / kg and CLt = 0,052 ± 0,035 L / h.