Posterhttp://hdl.handle.net/11617/62812024-02-25T05:16:50Z2024-02-25T05:16:50ZAntihypercholesterol Activity Of Ethanol Extracts Of Durian (Durio zibethinus Murr) and Longan (Euphoria longan Lamk) Fruit Peels on Male White Rats Wistar StrainMuhtadiSholikhah, Egy Nur HidayatusAzizah, TantiHaryotoSuhendi, Andihttp://hdl.handle.net/11617/66362018-03-19T04:07:02Z2014-06-06T00:00:00ZAntihypercholesterol Activity Of Ethanol Extracts Of Durian (Durio zibethinus Murr) and Longan (Euphoria longan Lamk) Fruit Peels on Male White Rats Wistar Strain
Muhtadi; Sholikhah, Egy Nur Hidayatus; Azizah, Tanti; Haryoto; Suhendi, Andi
Durian (Durio zibethinus Murr) and longan (Euphoria longan Lamk) fruit peels contain flavonoid compounds that might have potential activity as antihypercholesterol. The purpose of this study to determine the antihypercholesterol effect of ethanol extract of durian and longan fruit peels on the white rats Wistar strain. The research method is the pre and post control group design. Fourty rats were divided to 8 treatment groups. Group I (negative control) were given CMC-Na 0,5%, group II (positive control) were given Colestiramine 0,8 g/kgBW, group III, IV, V, VI, VII and VIII treated by ethanol extract of durian and longan fruit peels with consecutive doses 125, 250, and 500 mg/kgBW. Before treatment, the rats were given high cholesterol diets and fed diets supplemented with cholesterol during 4 weeks. The composition of high cholesterol diets were cooking oil, quail egg yolk, water, PTU (Propyltiourasil) and fed diets supplemented with cholesterol were margarine, quail egg yolk, standard feed. The treatment of antihypercholesterol testing on the rats conducted for 2 weeks. The result showed that durian and longan fruit peels ethanol extracts have potential antihypercholesterol activity. Percentage decreasing of cholesterol total level of ethanol extract of durian and longan fruit peels with consecutive doses 150, 250, and 500 mg/kgBW were 12.56%, 35.79%, 35.82%, 27.61%, 33.56%, 33,97%, respectively. While Colestiramine 0.8 g/kgBW as a positive control had value decreasing percentage of total cholesterol was 34.20%
2014-06-06T00:00:00ZAntioxidant Activity, Total Phenolic and Flavonoid Contents of Ethanolic Extracts of Local Longan (Euphoria Longan Lour.) Seeds and RindsMuhtadi, MuhtadiAnnida, RifkaMelannisa, RositaHaryoto, HaryotoAzizah, TantiIndrayudha, PeniSuhendi, Andihttp://hdl.handle.net/11617/62822018-03-19T04:04:01Z2013-10-29T00:00:00ZAntioxidant Activity, Total Phenolic and Flavonoid Contents of Ethanolic Extracts of Local Longan (Euphoria Longan Lour.) Seeds and Rinds
Muhtadi, Muhtadi; Annida, Rifka; Melannisa, Rosita; Haryoto, Haryoto; Azizah, Tanti; Indrayudha, Peni; Suhendi, Andi
The antioxidant, total phenolics and flavonoid content of local Longan (Euphoria longan Lour.) seeds and rinds were determined. The antioxidant activity test of ethanolic extract, hexane, ethyl acetate and methanol-water fractions of local longan seeds and rinds were evaluated by DPPH (2,2-diphenyl-1-picrilhydrazil) method. The total phenolic contents and total flavonoid contents were assessed spectrophotometrically. The results showed that the fraction of ethanol extract, ethyl acetate and methanol-water of longan seeds and rinds had high antioxidant activity whereas the hexane fraction had lowest activity. The highest activity was indicated of the ethyl acetate fraction longan rinds (IC50 = 9.23 µg/ml), ethyl acetate fraction longan seeds (IC50 = 9.50 µg/ml), and wasn’t significantly differ with vitamin E (IC = 8.88 µg/ml). The total phenolic content of the ethanol extract of longan rinds and seeds as well as fractions ranged from 8.72 ± 0,64 to 692.85 ± 41.11 mg/g sample. Whereas the total flavonoid levels in the samples ranged from 80.64 ± 6.98 to 680.15 ± 40.94 mg/g sample.
2013-10-29T00:00:00Z