Proceedings of International Current Breakthrough (ICB)-Pharma
http://hdl.handle.net/11617/10933
2024-02-25T05:17:01ZCharacteristics Testing of Microcrystalline Cellulose from Nata de Coco Compared to Avicel pH 101 and Avicel pH 102
http://hdl.handle.net/11617/6204
Characteristics Testing of Microcrystalline Cellulose from Nata de Coco Compared to Avicel pH 101 and Avicel pH 102
Yugatama, Adi; Maharani, Laksmi; Pratiwi, Hening; Ikaditya, Lingga
Microcrystalline cellulose is an imported raw material in Indonesia, which used widely as an excipient in tablet production. One of the alternative materials to produce microcrystalline cellulose is from nata de coco. This research aimed to know the characteristic of microcrystalline cellulose from nata de coco compared to avicel pH 101 and avicel pH 102. Nata de coco were alkalinated, dried and hydrolyzed to get microcrystalline cellulose. Independent variables in this research are microcrystalline cellulose from nata de coco, avicel pH 101 and avicel pH 102. While the dependent variables are flow properties, compactibility, compressibility, water absorption, tap density, bulk density, loss of drying, infrared absorption spectra, and SEM images. Data analyzed using one way ANAVA with CI 95% and using software SPSS for windows. The result showed that data from characteristic test microcrystalline cellulose from nata de coco is different in flow properties, compactibility, compressibility, tap density, bulk density, and loss of drying from avicel pH 101 and avicel pH 102, but having the same water absorption. Infrared spectrum data showed that microcrystalline cellulose from nata de coco is similar to avicel pH 101 and avicel pH 102. The SEM result showed that microcrystalline cellulose from nata de coco having bigger particle size (66.67–266.67 μm) than avicel pH 101 (13.33–166.67 μm) and avicel pH 102 (13.33–200 μm).
2015-10-30T00:00:00ZPreparation of Artificial Saliva Formulation
http://hdl.handle.net/11617/6203
Preparation of Artificial Saliva Formulation
Amal, Andi Sri Suriati; Hussain, Samsinah; Jalaluddin, Mohd. Amin
Dry mouth or throat (xerostomia) is a clinical condition characterized by desiccation of the intraoral tissues. Patients with chronic or temporary sensation of dry mouth need some kind of treatment to relieve the symptoms. Causes of dry mouth include medications, autoimmune disease (Sjogren’s syndrome), radiotherapy or chemotherapy for cancer, hormone disorders and infections. The project is important not only because saliva substitutes are not manufactured locally, but also because most saliva substitutes use mucin (porcin in origin). Therefore there is a need to produce one with other source which has properties to mucin itself. The objective of this project is to produce saliva substitutes that can serve as mouth and throat lubricants. The first step was pre-formulation studies that involved characterization of active ingredients (physical, chemical, and mechanical properties) in order to choose what other ingredients (excipients) should be used in the preparation. Formulation studies also considered such factors as solubility, viscosity, and pH. The last step was assessment of safety and stability of the final product. The new artificial saliva formulations containing various ratios of SCMC (Sodium carboxymethyl cellulose), MC (methyl cellulose) and HPMC (hydroxypropyl methycellulose) have been developed. Combination of cellulose derivatives and albumin in these formulations resulted in the physical properties of these new artificial saliva substitutes closely resembling human saliva and mucin-based saliva substitutes. Formula we choose were the most suitable formulae due to their viscosity and pH properties which closely resemble human saliva and mucin based saliva substitutes.
2015-10-30T00:00:00ZPreparation and Characterization of Submicron Particles of PLGA Incorporating Rifampin Using Emulsion Solvent Diffusion Method
http://hdl.handle.net/11617/6202
Preparation and Characterization of Submicron Particles of PLGA Incorporating Rifampin Using Emulsion Solvent Diffusion Method
Mardiyanto
The research had been performed to incorporate rifampin into PLGA submicron-sized particles. This research has a prospect to be applied to overcome the ineffectiveness use of rifampin for tuberculosis patients as rifampin was not stable in human lung macrophages, while Mycobacterium tuberculosis was able to survive in human lung macrophages. Rifampin was incorporated into submicron particles of PLGAs using the emulsion solvent diffusion method. The use of rifampin 50 mg in every batch resulted in the submicron-sized particles of 220 nm, PDI 0:12, zeta potential 21 mV and EE 37%. In the batch using rifampin 300 mg, resulted the submicron-sized particles of 410 nm, PDI 0:22, zeta potential 14 mV and EE 40%. The surface of the particles was visualized by SEM and hydrodynamic size compared to TEM. It was known that particle is spherical with a smaller diameter than the hydrodynamic size. TEM measurement revealed the size of particles with PVA was 208 nm.
2015-10-30T00:00:00ZLiquid Bath Soap Formulation and Antibacterial Activity Test Against Staphylococcus aureus of Kecombrang (Etlingera elatior (Jack) R.M.Sm.) Flos Extracts
http://hdl.handle.net/11617/6201
Liquid Bath Soap Formulation and Antibacterial Activity Test Against Staphylococcus aureus of Kecombrang (Etlingera elatior (Jack) R.M.Sm.) Flos Extracts
Handrayani, Lilis; Aryani, Ratih; Indra
The formulation of kecombrang flos extract (Etlingera elatior (Jack) R.M.Sm.) liquid bath soap has been established. The objective of this research was to formulate liquid bath soap of kecombrang flos extract (Etlingera elatior (Jack) R.M.Sm.) and to test its antibacterial activity to Staphylococcus aureus. Kecombrang flos extract was extracted by maceration method using 96% ethanol, and followed by minimum inhibitory concentration (MIC) test using hole method. Concentration variation of kecombrang flos extract was conducted as F1 (6%), F2 (8%), and F3 (10%). The formula of liquid bath soap of kecombrang flos extract was evaluated using several examinations such as organoleptic, pH, viscosity, density, foaming stability, antibacterial activity test, irritation test and hedonic test. The result shows the liquid bath soap of kecombrang flos extract F1, F2 and F3 can inhibit the growth of Staphylococcus aureus. Based on statistical test using SPSS 21 (for trial) ANOVA method continued by LSD shows that F0 (negative control), F1, F2, F3 and positive control (triclosan 2.5%) have difference meaningful result with significance value < 0,05.
2015-10-30T00:00:00Z