International Seminar on Natural Product Medicines
http://hdl.handle.net/11617/5300
2024-03-29T09:50:10ZAntibacterial Activity of Pawpaw (Carica papaya) against Multidrugresistant Staphylococcus aureus and Multidrug-Resistant Escherichia Coli
http://hdl.handle.net/11617/5302
Antibacterial Activity of Pawpaw (Carica papaya) against Multidrugresistant Staphylococcus aureus and Multidrug-Resistant Escherichia Coli
Yuliani, Ratna; Indrayudha, Peni; Setyawan, Wahyu; Soranta, Eko Wahyu; Haptiasari, Eriana
This study was designed to evaluate in vitro antibacterial activity of several part of pawpaw (Carica
papaya) against multidrug-resistant bacteria. Leaves, stems, and roots were extracted with ethanol
and tested for in vitro antibacterial activity using agar dilution method against multidrug-resistant
Staphylococcus aureus and multidrug-resistant Escherichia coli. Stems extracts show highest
antibacterial activity against the test bacteria with minimum inhibitory concentration (MIC) value of
30 mg/mL for both bacteria. Leaves and roots extract have antibacterial activity against multidrugresistant
Staphylococcus aureus with MIC values of 70 and 50 mg/mL, respectively. The MIC
values of leaves and roots extract on multidrug-resistant Escherichia coli were 80 and 70 mg/mL,
respectively. Several phytochemicals in the extracts are responsible for the antibacterial activity.
2012-11-01T00:00:00ZAntibacterial Activity of 3,6-Bis [(4-Hydroxy-3,5-Dimethylphenyl)Methylidene] Piperazine-2,5-Dione against Staphylococcus aureus, Escherica coli and Bacillus subtilis
http://hdl.handle.net/11617/5301
Antibacterial Activity of 3,6-Bis [(4-Hydroxy-3,5-Dimethylphenyl)Methylidene] Piperazine-2,5-Dione against Staphylococcus aureus, Escherica coli and Bacillus subtilis
Santoso, Broto; Shani, Yasinta M; Haryoto; Ulfa, Amelia M
Curcumin has antibacterial activity. Modification of curcumin to obtain a more potent compound, stable, safe, effective, and has a better activity has been widely applied. Some of them are derived compounds of pentagamavunon (PGV) and derivatives of piperazine-2,5-dione. Molecule of 3,6-bis[(4-hydroxy-3-methoxy)metiliden]piperazine-2,5-dione (DKP1) and 3,6-bis[(4-hydroxy-3,5-dimetilphenyl)metiliden]piperazine-2,5- dione (DKP2) are derivates of piperazine-2,5-dione. This study aims to determine the antibacterial activity of DKP1 and DKP2 against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis. The antibacterial assay was done using Kirby Bauer diffusion method. Dics were impregnated with curcumin, PGV-0, PGV-1, DKP1 and DKP2. The discs were place on Mueller Hinton media that has been inoculated with the test bacteria. Antibacterial activity was determined by measuring inhibition zone around the discs. The results showed that DKP2 has weak antibacterial activity against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. Pentagamavunon-0 (PGV-0) has activity against E. coli and along with PGV-1 against Staphylococcus aureus. Curcumin and DKP1 have no antibacterial activity against Staphylococcus aureus, and along with PGV-0 and PGV-1 against Bacillus subtilis.
2012-11-01T00:00:00Z