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| dc.description.abstract | Purpose: The purpose of this study was to evaluate the anti-inflammatory activity of cinnamic acid
and 3-phenyl propanoic acid and also virtual screening of the methyl trans-cinnamate derivatives were
carried out on the COX-2 enzyme.
Methodology: The cinnamic acid and 3-phenylpropanoic acid were tested for anti-inflamatory activity in
vivo using carageenan-induced rat paws edema method. Thirty male Sprague-Dawley rats were divided
into 5 groups: control group, Na diclofenac (0.45 mg/kg body weight), ibuprofen (7.2 mg/kg body
weight ), cinnamic acid (14.4 mg/kg body weight) and 3-phenyl propionate acid (14.4 mg/kg body
weight). Paw edema was observed using a plethysmometer for 46 hours, these were at 0, 0.5, 2, 3, 4, 5,
22, 29 and 46 hours. Each compound of methyl trans-cinnamate derivatives to be performed molecular
docking, virtual constructed in the form of two-dimensional (2D) using BKChem application. The
simulation molecular docking using PLANTS 1.1. The structure of methyl trans-cinnamate derivatives
was characterized by IR, melting point, UV, 1H NMR, 13C NMR, and mass spectral analysis.
Results: The result showed that antiinflamatory activity of Na diclofenac, ibuprofen, cinnamic acid, and
3-phenil propionic acid were -20,6 %, -3,7 %, -43,2 %, 27,7 % respectively. These results showed only
3-phenil propionic acid could reduce edema in the rats’ paw. The docking results show that cinnamic
acid, 3-phenyl propanoic acid and 3- (4-benzoylphenyl) propanoic acid are predict to have activity as
COX-2 inhibitors. | id_ID |
