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Effect of Green Tea Extract to the Degree of Knee Joint Damage and Nitric Oxide Levels in the Rabbit Osteoarthitis Model

dc.contributor.authorSusmiarsih, Tri Panjiasih
dc.contributor.authorHadi, Restu Syamsul
dc.contributor.authorSofwan, Achmad
dc.contributor.authorKuslestari, K
dc.contributor.authorRazari, Intan
dc.date.accessioned2020-01-22T02:40:22Z
dc.date.available2020-01-22T02:40:22Z
dc.date.issued2019
dc.identifier.citationAbramson SB. Osteoarthritis and nitric oxide. Osteoarthritis and Cartilage. 2008. 16, Supplement 2, S15–S20 Ahn JK, Koh EM, Cha HS, Lee YS, Kim J, Bae EK, Ahn KS. Role of hypoxia-inducible factor- 1alpha in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblastlike synoviocytes. Rheumatology (Oxford) 2008;47:834–839. doi: 10.1093/rheumatology/ ken086. Akhtar N, Haqqi TM: Current nutraceuticals in the management of osteoarthritis: a review. Ther Adv Musculoskelet Dis 2012, 4:181–207. Alghadir AH, Gabr SA, AL-Eisa ES. Green tea and exercise interventions as nondrug remedies in geriatric patients with rheumatoid arthritis. J Phys Ther Sci. 2016 Oct;28(10):2820-2829. Epub 2016 Oct 28.10.1589/jpts.28.2820. Appleton C. T. (2018). Osteoarthritis year in review 2017: biology. Osteoarthr. Cartil. 26 296–303. 10.1016/j.joca.2017.10.008. Chou LW, Wang J, Chang PL, Hsieh YL.Hyaluronan modulates accumulation of hypoxiainducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model.Arthritis Res Ther. 2011 Jun 16;13(3):R90. doi: 10.1186/ar3365. Farrell AJ, Blake DR, Palmer RM, Moncada S. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis. 1992;51:1219–1222. doi: 10.1136/ard.51.11.1219. Feldmann M, Maini SR. Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics. Immunol Rev. 2008, 223: 7–19. Flemming D. J., Gustas-French C. N. (2017). Rapidly progressive osteoarthritis: a review of the clinical and radiologic presentation. Curr. Rheumatol. Rep. 19:42. 10.1007/s11926-017-0665- 5. Gabr SA, Alghadir AH, Ghoniem GA. Regulation of cartilage and inflammatory biomarkers in rheumatoid arthritis patients treated with green tea therapy. Afr. J. Pharm. Pharmacol. 2014.8(10), pp. 263-273.10.5897/AJPP2013.3710. Glyn-Jones S., Palmer A. J., Agricola R., Price A. J., Vincent T. L., Weinans H., et al. (2015). Osteoarthritis. Lancet 386 376–387. 10.1016/s0140-6736(14)60802-3. Graham H.N. Green tea composition, consumption, and polyphenol chemistry. Prev. Med. 1992;21:334–350. doi: 10.1016/0091-7435(92)90041-F. Haqqi TM, Anthony DD, Gupta S, Ahmad N, Lee MS, Kumar GK, Mukhtar H. Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci U S A. 1999;96:4524–4529. doi: 10.1073/pnas.96.8.4524. Heinecke LF, Grzanna MW, Au AY, Mochal CA, Rashmir-Raven A, Frondoza CG: Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate. Osteoarthritis Cartilage 2010, 18:220– 227. Hsu CC, Lin CL, Jou IM, Wang PH, Lee JS.The protective role of nitric oxide-dependent innate immunosuppression in the early stage of cartilage damage in rats: Role of nitric oxide in cartilage damage. Bone Joint Res.2017 Apr;6(4):253-258. doi: 10.1302/2046-3758.64.BJJ- 2016-0161.R1. Hu J, Webster D, Cao J, Shao A. The safety of green tea and green tea extract consumption in adults – Results of a systematic review. Regulatory Toxicology and Pharmacology. 2018. 95:412-43. 10.1016/j.yrtph.2018.03.03. Jotanovic Z., Mihelic R., Sestan B., Dembic Z. (2012). Role of interleukin-1 inhibitors in osteoarthritis: an evidence-based review. Drugs Aging 29 343–358. 10.2165/11599350- 000000000-00000. Khokhar S, Magnusdottir SGM. Total Phenol, Catechin, and Caffeine Contents of Teas Commonly Consumed in the United Kingdom.J. Agric. Food Chem. 2002, 50, 3, 565-570. 10.1021/ jf0101531 Kon E, Filardo G, Drobnic M, Madry H, Jelic M, van Dijk N, Della Villa S. Non-surgical management of early knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2012;20:436– 449. doi: 10.1007/s00167-011-1713-8. Kun Li J, Liu XD, SheN L, Zeng W, Qiu G.Natural plant polyphenols for alleviating oxidative damage in man: Current status and future perspectives. Tropical Journal of Pharmaceutical Research May 2016; 15 (5): 1089-1098. Lana JFSD, Rodrigues BL. Osteoarthritis as a Chronic Inflammatory Disease: A Review of the Inflammatory Markers. Osteoarthritis as a Chronic Inflammatory Disease: A Review of the Inflammatory Markers. http://dx.doi.org/10.5772/intechopen.82565. Lapane KL, Yang S, Driban JB, Liu SH, Dube CE, McAlindon TE, Eaton CB. Effects of prescription nonsteroidal antiinflammatory drugs on symptoms and disease progression among patients with knee osteoarthritis. Arthritis Rheumatol.. 2015. 67(3):724-32. doi: 10.1002/art.38933. Le Graverand-Gastineau MP. Disease modifying osteoarthritis drugs: facing development challenges and choosing molecular targets. Curr Drug Targets 2010, 11:528–535. Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB. Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model.Arthritis Res Ther. 2014 Dec 17;16(6):508. doi: 10.1186/s13075-014-0508-y. Li G, Yin J, Gao J, Cheng TS, Pavlos NJ, Zhang C, Zheng MH. Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes.Arthritis Res Ther. 2013;15(6):223.10.1186/ar4405 Martel-Pelletier J, Wildi LM, Pelletier JP: Future therapeutics for osteoarthritis. Bone 2012, 51:297–311. Mereles D, Hunstein W: Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises?. Int J Mol Sci. 2011, 12: 5592-5603. 10.3390/ijms12095592 Olsen NJ: Nutraceuticals for the treatment of osteoarthritis. Minerva Med. 2011, 102:33–40. Pauli C1, Whiteside R, Heras FL, Nesic D, Koziol J, Grogan SP, Matyas J, Pritzker KP, D’Lima DD, Lotz MK. Comparison of cartilage histopathology assessment systems on human knee joints at all stages of osteoarthritis development. Osteoarthritis Cartilage. 2012 Jun;20(6):476- 85. doi: 10.1016/j.joca.2011.12.018. Epub 2012 Feb 18. Rainbow R, Ren W, Zeng L. Inflammation and Joint Tissue Interactions in OA: Implications for Potential Therapeutic Approaches. Arthritis. 2012;2012:741582. doi: 10.1155/2012/741582. Rutgers M, van Pelt MJ, Dhert WJ, Creemers LB, Saris DB. Evaluation of histological scoring systems for tissue-engineered, repaired and osteoarthritic cartilage. Osteoarthritis Cartilage. 2010;18:12–23. Singh R, Ahmed S, Islam N, Goldberg VM, Haqqi TM: Epigallocatechin-3-gallate inhibits interleukin-1β-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor κB activation by degradation of the inhibitor of nuclear factor κB. Arthritis Rheum. 2002, 46: 2079-2086. 10.1002/art.10443. Verma P., Dalal K. ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis. J. Cell. Biochem. 2011.112 3507–3514. 10.1002/jcb.23298.id_ID
dc.identifier.issn2615-1588
dc.identifier.urihttp://hdl.handle.net/11617/11828
dc.description.abstractOsteoathritis (OA) is characterized by degeneration of articular cartilage, subchondral bone, synovial fluid and synovium. Nitric oxide (NO) is proinflammatory cytokine that play a significant role in the pathogenesis of OA via cartilage and bone degradation by synovial inflammation. Green tea is a novel functional food for treating osteoarthritis and inhibiting the production of inflammatory mediators such as nitric oxide. This study aimed to evaluate the effects of green tea extract to the nitric oxide levels and degree of knee joint damage in the rabbit osteoarthitis model. The Freud’s adjuvant complete was performed to induce OA, as many as sixteen male rabbits (New Zealand white) were randomly divided into four groups: adjuvant injection, adjuvant and green tea (injection), adjuvant and green tea (per oral), and control group. The control group only received drinking water, the Freud adjuvant (0.2 ml) and green tea extract (200 mg/kg bw) were orally and injection administered for eight weeks. The articular cartilage damage was evaluated histologically according to MANKIN score. NO levels were determined by nitric oxide assay. Data was analysed by Chi square test. The result of this study showed the surface structure damage of cartilage increased after adjuvant-induced. Green tea extract decrease significantly (p=0.02) the degree of knee joint damage after adjuvant-induced in rabbit osteoarthritis models. NO levels increased after OA induction. The green tea extract administration (via injection) can significantly (p = 0.038) decrease NO levels compare to adjuvant group. Green tea extract decrease the knee joint damage and NO proinflamantory levels in rabbit of osteoarthritis model.id_ID
dc.language.isootherid_ID
dc.publisherISETH 2019 (International Summit on Science, Technology, and Humanity)id_ID
dc.titleEffect of Green Tea Extract to the Degree of Knee Joint Damage and Nitric Oxide Levels in the Rabbit Osteoarthitis Modelid_ID
dc.typeArticleid_ID


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