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| dc.description.abstract | The aim of this study was to determine the radioprotective effect of ethanolic roselle
extract in recurrent radiodiagnostic ionizing radiation on peripheral red blood cells of mice.
Forty eight male mice were used in this study and divided into 4 group; K-(physiological
saline without radiation), K+ (physiological saline with radiation), R- (roselle extract without
radiation), R+ (roselle extract with radiation). The mice were treated with 50 mg per kg body
weight roselle extract prior to radiation exposure. Following these treatment, the mice were
exposed with ionizing radiation at dose 0.2 mSv every two days for 8 weeks. Bloods sample
were collected from each group at week 0 before treatment, 2, 4, 6, and 8 week after
treatment. The bloods sample were taken at 4 and 8 week, which previously without radiation
exposure for 30 days as recovery phase. The result showed that radiation exposure caused an
increasing number of Mean Corpuscular Volume, Mean Corpuscular Hemoglobin, Mean
Corpuscular Hemoglobin Concentration and Howell Jolly Bodies in the peripheral blood
tissue. However, roselle extract caused a decreasing number of the parameters. This result
indicated that ethanolic roselle extract has radioprotective effect on red blood cells repair
process from ionizing radiation destruction. | en_US |
