| dc.identifier.citation | 1. Licciardi PV, Underwood JR. Plantderived medicines: A novel class of immunological adjuvants. Int. Immunopharmacol 2010;11:390-98. 2. Provenza FD, Villalba JJ. The role of natural plant products in modulating the immune system: An adaptable approach for combating disease in grazing animals. Small. Rum. Res. 2010;89:131-39. 3. Bouic PJD, Lamprecht JH. Plant sterols and sterolins: A review of their immunomodulating properties. Altern. Med. Rev. 1999;4(3):170-77. 4. Rajput ZI, Hu S, Xiao C, Arijo AG. Adjuvant effect of saponins on animal immune responses. J. Zhejiang Univ. Sci. B. 2006;8(3):153-161. 5. Mali RG, Hatapakki BC. An in vitro study of effect of Centella asiatica on phagocytosis by human neutrophils. Int. J. Pharm. Sci. Nanotechnol. 2008; 1(3):297-302. 6. Spelman K, Burns JJ, Nichols D, Winters N, Ottersberg S, Tenborg M. Modulation of cytokine expression by traditional medicines: A review of herbal immunomodulators. Altern. Med. Rev. 2006;11(2):128-150. 7. Zheng CJ, Qin LP. Chemical components of Centella asiatica and their bioactivities. J. Chinese Integr. Med. 2007;5(3):348-351. 8. Jayatirtha MG, Mishra SH. Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica. Phytomedicine 2004;11(4):361-65. 9. Punturee K, Wild CP, Kasinrerk W, Vinitketkumnuen U. Immunomodulatory activities of Centella asiatica and Rhinacanthus nasutus extracts. Asian Pac. J. Cancer Prev. 2005;6:396-400. 10. Akrom, Puspitosari D, Supriatno. Efek ekstrak etanol pegagan pada aktivitas sekresi reactive oxygen intermediates (ROI) makrofag peritoneal mencit Swiss betina diinduksi Spc-1. Jurnal Kedokteran Indonesia 2009;1(1):8-14. 11. George M, Joseph L, Ramaswamy. Anti-allergic, Anti-pruritic and anti-inflammatory activities of Centella asiatica extracts. Afr. J. Trad. CAM 2009;6(4):554-59. 12. Nakane A, Numata A, Asano M, Kohanawa M, Chen Y, Minagawa T. Evidence that endogenous gamma interferon is produced early in Listeria monocytogenes infection. Infect. and Immunity 1990;58(7):2386-88. 13. Wong P, Pamer EG. Feedback regulation of pathogen-specific T cell priming. Immunity 2003;18:499-511. 14. Zenewicz LA, Shen H. Innate and adaptive immune responses to Listeria monocytogenes: a short overview. Microbes and Inf. 2007;9:1208-15. 15. Shah SA, Sander S, Whitw CM, Rinaldi M, Coleman CI. Evaluation of Echinacea for the prevention and treatment of the common cold: a meta analysis. Lancet Infect. Dis. 2007;7:473-80. 16. Teixeira LK, Fonseca BPF, Barboza BA, Viola JPB. The role of interferon- on immune and allergic responses. Mem. Inst. Oswaldo Cruz 2005;100(1):137-44. | en_US |
| dc.description.abstract | Pegagan (Centella asiatica (L). Urban) is believed having immunostimulant potency;
several related study have been done, though its effect on interferon gamma (IFN- ) secretion
have not been reported. Hence, this study aimed at exploring the effect of ethanol extract of
Pegagan leave (Centella asiatica (L). Urban) on IFN- secretion on the spleen of Balb/C mice
infected by Listeria monocytogenes. This quasy experimental study was conducted toward 50
female Balb/C mice that were grouped into five, namely: group K which was a control group
that only given aquabidest; group EC-ZP given 1.95mg Echinacea and zinc pikolinat
suspension; and group EEP I, EEP II and EEPIII that given ethanol extract of C. asiatica (L).
Urban respectively at 50, 150 and 450mg/kgBW doses. The interventions were given for 14
days; on the day-15, all groups were infected with 104CFU L. monocytogenes intra
peritoneal. Observation of IFN- secretion were performed at day-2 and 4 after infection.
Results were analyzed by using analysis of variance to determine the statistical significance of
IFN- secretion between groups. This study showed that ethanol extract of C. asiatica (L).
Urban at 150mg/kgBW dose showed significantly higher IFN- secretion (p<0.05) compared
to control group at day-4 after infection but has no difference with ethanol extract of C.
asiatica (L). Urban at 50mg/kgBW dose. It can be concluded that at day-4 as peak of immune
response of L. monocytogenes infection, ethanol extract of C. asiatica (L). Urban at
150mg/kgBW dose enhance IFN- secretion. Further study is needed to explore the effect of
C. asiatica (L). Urban on other parameter of immune response related to IFN- secretion. | en_US |
