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dc.contributor.authorYuliani, Tri
dc.contributor.authorHandayani, S.
dc.contributor.authorAngelina, M.
dc.contributor.authorDewijanti, I.D.
dc.date.accessioned2012-12-14T07:50:02Z
dc.date.available2012-12-14T07:50:02Z
dc.date.issued2012-06
dc.identifier.citationAngelina, M., 2010, Aktivitas Kemopreventif Ekstrak Etanol Daun Brucea javanica Merrill Terstandar pada Tikus Putih, Tesis, Fakultas MIPA UI, Depok. Boyland, E., Sydnor K.L., 1962, The Induction of Mammary Cancer in Rats, Br J Cancer 16, 731-739. Departemen Kesehatan Republik Indonesia, 2008, Laporan Hasil Riset Kesehatan Dasar Nasional, Jakarta : Depkes RI. Feng W., Zhu, B., Zheng X., Zhang, Y., Yang, L., Li, Y.,2011, Chemical Constituents of Selaginella stautoniana,Chinese Journal of Natural Medicines 2011, 9(2): 0108−0111 Guruvayoorappan C, Kuttan G., 2008, Amentoflavone inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP- 9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, NM23 and cytokines in lung tissues of C57BL/6 mice, Immunopharmacol Immunotoxicol. 30(4):711-27. Hafidh R.R., Abas F., Abdulamir A.S., Jahanshiri F., Abu Bakar F. and Sekawi Z., 2009, A Review: Cancer Research of Natural Products in Asia. International Journal of Cancer Research, 5: 69-82. Handayani, S., 2011, Ekstrak Etanol Cakar Ayam (Selaginella sp.) Sebagai Obat Herbal Kanker Payudara, Laporan Penelitian, LIPI, Jakarta. Kleiner HE, Vulimiri SV, Reed MJ, Uberecken A, DiGiovanni, 2002, Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12- dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation, J.Chem Res Toxicol., 15(2), 226-35. Morales, D.E., McGowan K.A., Grant, D.S., Maheshwari, S., Bhartiya, D., Cid, M.C., Kleinman, H.K., Schnaper, H.W., 1995, Estrogen Promotes Angiogenic Activity in Human Umbilical Vein Endothelial Cells In Vitro and in a Murine Model, Circulation.,91, 755-763. Pradhan S.N., Chung, E.B., Gosh, B., Paul, B.D., Govind, J.K., 1974, Potential Carcinogens. I. Carcinogenicity of Some Plant Extracts and Their Tannin-Containing Fractions in Rats, JNCI J Natl Cancer Inst 52 (5): 1579- 1582. doi: 10.1093/jnci/52.5.1579 Pugazhendhi D, Pope GS, Darbre PD., 2005, Oestrogenic activity of phydroxybenzoic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines, J Appl Toxicol.;25(4):301-9. Rice, S., Whitehead, S.A., 2006, Review: Phytoestrogens and breast cancer – promoters or protectors?, Endocrine- Related Cancer, 13 995–1015 Sadek, I.A., Abdul-Salam, F., 1994, Effect of Dietary Fat on Toad Liver Tumor Induced by DMBA: Ultrastructural Studies, Histol Histopath., 9, 423-426. Setyawan1 A.D., 2011, Review: Recent status of Selaginella (Selaginellaceae) research in Nusantara, Biodiversitas; 2(12): 112-124 Setyawan2 A.D., 2011, Review: Natural products from Genus Selaginella (Selaginellaceae), Nusantara Bioscience 3(1), Pp.: 44-58 Yoon SO, Shin S, Lee HJ, Chun HK, Chung AS.,2006, Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression, Mol Cancer Ther. 5(11): 2666-75.en_US
dc.identifier.isbn978-602-18711-0-2
dc.identifier.urihttp://hdl.handle.net/11617/2353
dc.description.abstractOur previous study shown that ethanolic extract of Selaginella sp. (EES) has cytotoxic activity against cancer cell. In this current study, its effects on DMBA-induced tumor in female Sprague Dawley rats in vivo were investigated. The rats were divided randomly into 5 groups (8 rats each) named P (healthy control), Q (cancer control), R (treatment group, EES Dose 250 mg/kgbw), S (treatment group, EES Dose 500 mg/kgbw), and T (treatment group, EES Dose 750 mg/kgbw). EES in aquadest solution was administered orally for 7 weeks. DMBA in corn oil solution as tumor inducer was administered orally in 3 times. The rats were checked daily for mammary tumors by palpation after 7 weeks administration for 16 weeks. Macroscopic observations on vital organs of the rats were done during necropsy. This study showed that the number of rats suffered from tumor was declined in the higher dose. The highest dose in treatment group had the smallest number of tumor compare to the other treatment groups, but gave the highest mortality (50%), though 25% rats had no tumor and showed great body weight gain. In summary, the highest dose had not shown significant chemoprevention activity yet. Further study using higher doses is needed.en_US
dc.language.isoenen_US
dc.publisherMuhammadiyah University Pressen_US
dc.subjectratsen_US
dc.subjecttumoren_US
dc.subjectDMBAen_US
dc.subjectmortalityen_US
dc.subjectSelaginella spen_US
dc.titleEffects of Ethanolic Extract of Selaginella sp. on DMBA-induced Carcinogenesis in Female Sprague Dawley Ratsen_US
dc.typeArticleen_US


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