The Influence of Avicel PH 102 as Filler-Binder Agent and Explotab as Disintegrant Agent Against Andrographolide Dissolution Rate Of Sambiloto Extract Tablets
Kusumadewi, Awal P.
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Sambiloto (Andrographis paniculata Ness) is one of the constituent materials traditional medicine concoction as anti-diabetes on the various dosage forms, such as powder, capsule, and tablet. Avicel is one of the pharmaceutical filler-binder agents on the direct compression tablet. Explotab is disintegrator agent in tablet formulation, by either direct compression or wet granulation process. The aim of this research is to find out the influence of Avicel PH 102 and Explotab againts andrographolide dissolution rate of sambiloto extract tablets. The tablets were made by direct compression with factorial design 22 using 20% and 90% Avicel PH 102 and 2% and 8% EXPLOTAB, of extracts weight, respectively, were independent variables. The dissolution andrographolide response as dependent variables. The experiment was conduct in the formulation technology laboratory, Universitas Gadjah Mada, Yogyakarta. Based on dissolution rate data, the formulation are expressed in the factorial experimental design: Y = 34.52 + 33.37Xa + 12.54Xb + 11.39XaXb, which figured out the influence of Avicel PH 102 (Xa), Explotab (Xb) and their interaction (XaXb). The Avicel PH 102, Explotab, and their interaction significantly increase the andrographolide dissolution rate of the sambiloto’s extract tablet, while Avicel PH 102 dominantly increase the dissolution rate (Q45) of andrographolide.