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dc.contributor.authorSujono, Tanti Azizah
dc.date.accessioned2013-01-19T07:50:24Z
dc.date.available2013-01-19T07:50:24Z
dc.date.issued2010-09
dc.identifier.citationAnonim, 1979, Farmakope Indonesia, Edisi III, 37, Departemen Kesehatan Republik Indonesia, Jakarta. Anonim, 1986, Sediaan Galenik, Departemen Kesehatan Republik Indonesia, Jakarta. Anonim, 1988, Panduan Pelayanan Informasi Obat, 15-16, PT Kimia Farma, Jakarta. Anonim, 2006, Antioksidan, Resep Sehat dan Umur Panjang, (Online), (http://www.indonesiamedia.com/2004/08/early/kesehatan-080 antioksidan.htm, diakses 1 Oktober 2007). Ansel, H. C., 1989, Pengantar Bentuk Sediaan Farmasi, Edisi IV, 605-609, Universitas Indonesia Press, Jakarta. Arora, D., 1986, Mushrooms Demystified, 2nd edition, Ten Speed Press. Aslam, M., Tan, C. K., dan Prayitno, A., 2003, Farmasi Klinis: Menuju Pengobatan Rasional dan Penghargaan Pilihan Pasien, 155, 156, 157- 158, PT Elex Media Komputindo Kelompok Gramedia, Jakarta. Boyn, W., 1953, A Textbook of Pathology Structure and Function in Disease, 7th ed, 783, Lea and Febiger, Philadelpia. Chan K, Han XD, Kan YW. 2001. An Important Function of nrf2 in Combating Oxidative Stress: Detoxification of Acetaminophen. Proc Natl Acad Sci 98 (8): 4611 – 4616. Darmawan, S., 1973, Hati Dan Saluran Empedu, Dalam Himawan S., (editor), Patologi, 227, 230, Bagian Patologi Anatomi Fakultas Kedokteran Universitas Indonesia, Jakarta. Donatus, I. A., 1983, Parasetamol: Kinetik Absorbsi, Distribusi dan Eliminasinya Pada Tikus Putih Jantan dalam Keadaan Defisiensi Vitamin E, Tesis, 12-14, Universitas Gadjah Mada, Yogyakarta. Donatus, I. A., 1994, Antaraksi Kurkumin dan Paracetamol: Kajian Terhadap Aspek Farmakologi dan Toksikologi Perubahan Hayati Parasetamol, Disertasi, 133, 148, 155, Universitas Gadjah Mada, Yogyakarta. Donatus, I. A., 1998, Peran Fitofarmaka Dalam Upaya Pengobatan Hepatitis, Kumpulan Naskah Lengkap Simposium Nasional Hepatitis, Yogyakarta. Fischbach, F. T., 1988, A Manual of Laboratory Diagnostic Tests, Third Edition, 304, J. B. Lipincott Company, Philadelphia. Gilbertson, R. L., &. Ryvarden, L, 1986, Nort American Polypores, Fungiflora, p.299-300, Norway. Gillete JR. 1981. An Integrated Approach to the Study of Chemically Reactive Metabolites of Acetaminophen. Arch Intern Med 141:375-379. Gips, C. H., dan Wilson, J. H. P., 1989, Diagnosis dan Terapi: Penyakit Hati dan Empedu, Diterjemahkan oleh Effendi, I., Hipokrates, Jakarta. Gunawan, A., 2000, Food Combining, Gramedia Pustaka Utama, Jakarta Guyton and Hall. 1997. Textbook Of Medical Physiology. Penerbit Buku Kedokteran EGC, Jakarta. Hayes, M.A., 2007. Pathophysiology of the Lliver. Saunder Company, USA. Hirotani, M., C. Ino, and T. Furuya., 1993, Biosynthesis of Cryptoporic Acids H and I in Ganoderma Neo-Japanicum, Phytochemistry, 32(4): 891-896. Hushada, Y., 1996, Fisiologi dan Pemeriksaan Biokimia Hati, 11, Dalam Syaiffoelloh N., (Editor Kepala), Buku Ajar Ilmu Penyakit Dalam, Edisi III, Jilid I, 224-226, Balai Penerbit Fakultas Kedokteran Universitas Indonesia, Jakarta. Hseu, R. S., Wang, H. H., & Wang, H. F., 1996, Differentiation and Grouping of Isolated of Ganoderma lucidum Complex by Random Amplified Polymorphic DNA-PCR Compared with Grouping on the Basis og Internal Transcribed Spancer Sequence, Apllied Microbiology Laboratory, Departemant of Algricultual Chemistry, National Taiwan University, Taipe, Taiwan, Republic of China. John, C., & Tina, C., 2004, Lingzhi (Ganoderma), Chinese Medical Herbology and Pharmacology, Chapter 14 – Section 2 Nourishing Herbs that Calm the Shen (Spirit), Art of Medicine Press. www.AOMpress.com. Jong. S. G., & Birmingham, 1992, Medical Benefit of the Mushroom Ganoderma Javanes in Apllied, Micro-Biology 37: 101-107. Jungueira, L. C., & Carneiro, J., 1980, Basic Histology, 354, Lange Medical Publications, California. Kirsch, R., Robson, S., and Meissner, P., 1991, Liver Update 1991, 11-13, Medical Research Council, Cape Town. Lehninger, A. L., 1993, Dasar-Dasar Biokimia, Jilid I, Diterjemahkan oleh M. Harnawijaya, Erlangga, 144-145, Surabaya. Lin C. G., & Bing Z. Z., 1985, Clinical Journal of Hepatic and Gallbladded Diseases; 4:242, Republic of China. Lu, F. C., 1995, Toksikologi Dasar: Asas, Organ Sasaran dan Penilaian Resiko, Diterjemahkan oleh Nugroho, E., Edisi Kedua, 208, 210, 216-217, Universitas Indonesia Press, Jakarta. Mitruka,M. 1981. Clinical Biochemical and Hematological Reference Values in Normal Experimental Animals and Normal Humans. Second Edition. Masson Publishing. USA Muchayat, S., 2004, Fibronectine Serum sebagai Biomarker Prediktor Fibrosis pada Penderita kronik Hepatitis dan Serosis Hati, (Online), (http://www.lisaira@litbang.depkes.go.id/jkpkbbk-gdl-res-2004- muchayat2c- 2130-fibrosis, diakses tanggal 28 November 2007). Ng, P. C., Y. C. Kong, K. M. Ko, C. M So, P. K. Yick, & H. Schilcher. 1993. Antioksidant activity of Ganoderma lucidum: Protective Effect on Carbon Tetracchloride-Induced Hepatoxicity. Acta-Holticultura 332: 219-225. Noer, H. M. S., 1987, Fisiologi dan Pemeriksaan Biokimiawi Hati, Editor Soeparman, Ilmu Penyakit Dalam, Jilid I, Edisi Kedua, 541-546, Balai Fakultas Kedokteran Universitas Indonesia, Jakarta. Nurul, T., 1999, Kelainan Hati Akibat Obat, Buku Ajar Ilmu Penyakit Dalam, Edisi I, Fakultas Kedokteran Universitas Indonesia, Jakarta. Ody, P., 2000, Complete Guide Medical Herbal, Darling Dersely Book, 144-145, Australia. Plaa, G. L., 1975, Toxicology of the Liver, incassarett, L. J., & Doull, J., Toxicology Basic Science of Poison, 171-179, Mac Millan Publishing Co. Inc., New York. Price, S. A., & Wilson, L. M., 2005, Patofisiologi: Konsep Klinis Proses-Proses Penyakit, 473-476, Edisi 6, Volume 1, Penerbit Buku Kedokteran EGC, Jakarta. Quanten, E., 1993, Study of the Polyporaceae of Papua New Guinea, Eliminary Polypore, Disertasi yang tidak dipublikasikan, Limburgs. Rahmawati, N. S. H., 2010, Efek Hepatoprotektif Ekstrak Air Jamur Lingzhi (Ganoderma lucidum) pada Tikus Jantan Terinduksi Parasetamol, Skripsi, Fakultas Muhammadiyah Surakarta, Surakarta. Rifai, M. A., 1990, Flora Jamur Kebun Raya Bogor, Buletin Kebun Raya Indonesia: 24-32, Bogor. Rosnalini, 1995, Optimasi Dosis Kurkumin Sebagai Hepatoprotektor pada Tikus, Skripsi, Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta. Ryvarden, L., & Gilbertson, 1993, Opean Polypores, Fungiflora, p. 175-176,275-276, Norway. Siswosudarmo, R., & Djoko, P., 1979, The Toxic Effect of Paracetamol on Mice Liver in Vitro, Departemen of Anatomy, Faculty of Medicine, GMU, Yogyakarta. Sodeman, A. W., & Thomas, M. S., 1995, Patofisiologi (Pathologic Physiology Mechanism of Disease), Edisi Ke tujuh, Jilid II, 595-596, Alih Bahasa oleh Hartono, A. dkk., Penerbit Buku Kedokteran EGC, Jakarta. Susanto, A., 1998, Sifat-Sifat Biokimiawi dan Fabrikasi Ganoderma, Jamur Patogen Pohonan, Jurnal Perlindungan Tanaman Indonesia, vol. 4. No. 2, 83-91, Pusat Penelitian Kelapa Sawit, Medan. Tabbu, C. R., 1991, Patologi Umum, Bagian I, 40, Laboratorium Fakultas Kedokteran Hewan Universitas Gadjah Mada, Yogyakarta. Tambunan, G. W., 1994, Patologi Gastroenterologi, 143, Bagian Patologi Anatomi Fakultas Kedokteran Universitas Sumatra Utara, Penerbit Buku Kedokteran EGC, Jakarta. Tirmenstein MA, and Nelson SD. 1990, Acetaminophen-Induced Oxidation of Protein Thiols: Contribution of Impaired Thiol-Metabolizing Enzymes and the Break down of Adenin Nucleotides. J Biol Chem 265 (6): 3059 – 3065. Underwood, J. C. E., 1999, Patologi Umum dan Sistemis, Diterjemahkan oleh Sarjadi, Edisi II, 170-171, Penerbit Buku Kedokteran EGC, Jakarta. Voigt, 1971, Buku Pelajaran Teknologi Farmasi, 561-617, Gadjah Mada University Press, Yogyakarta. Wenas, N. T., 1996, Kelainan Hati Akibat Obat, Dalam Syaifoellah, N., (Editor Kepala), Buku Ajar Ilmu Penyakit Dalam, Edisi III, Jilid I, 366, Balai Penerbit Fakultas Kedokteran Universiatas Indonesia, Jakarta. Wijoyo, Y., 1998, Sari Wortel (Daucus carota, L.) Parasetamol Kajian terhadap Kehepatoprotektifan dan Kajian Toksikokinetik Parasetamol pada Tikus, Skripsi, 1998, Universitas Gadjah Mada, Yogyakarta. Zimmerman, H. J., 1978, Hepatotoxsicity, 46-51, 95-101, 103-110 225-227, Appleton Century Croftts, New York. Zhou, Sh., Gao, Y., Chen, G., Dai, X., Ye, J., & Gao, H. A., 2002, Study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. (Ling Zhi, Reishi mushroom) Extract in Patients With Chronic Hepatitis B. Int. J. Med. Mushrooms, Phase I-II, 2002, 4 (4), 321–328, Republic of China.en_US
dc.identifier.urihttp://hdl.handle.net/11617/2529
dc.description.abstractLiver disease can be caused by virus, bacterium, parasite, drugs, alcohol, worm, or bad nutrition. One of drug which causing disease at liver is paracetamol where excessive usage or over dose will cause liver necrosis. Lingzhi (Ganoderma lucidum) contain ganodermic acid to restore liver function. Purpose of this research is to know hepatoprotective effect of ethanol extract lingzhi on the male rats that inducted by paracetamol. The research was conducted in five groups of male rats (each group contain five rats). The first group (normal control), the second group (control of toxic paracetamol 2,5 g/kg bw), the third until fifth group, were given Ganoderma lucidum extract with doses 0,5; 1 and 2 g/kg bw respectively. 24 hours after treatment, they were administrated by toxic dose paracetamol 2,5 g/kg bb. After 48 hours, SGPT activity were measured by GPT ALAT method and then their liver cells were examined by histology preparation. The results showed that the administered single dose of extract Ganoderma lucidum doses 0,5 : 1, and 2 g/kg bw for 7 seven days have a significant hepatoprotective effect in male rats 81,91%; 85,50% and 96,82% respectively. The examination of the liver cells by histology preparation shown that the administration of alcohol extract of Ganoderma lucidum doses 0,5; 1, and 2 g/kg bw have significant hepatoprotective effect againts toxicity of parasetamol (can reduce necrosis in liver).en_US
dc.description.sponsorshipDOSEN MUDA DIKTIen_US
dc.publisherLPPM UMSen_US
dc.subjectHepatoprotective effecten_US
dc.subjectGanoderma lucidumen_US
dc.subjectGPT (Glutamat Piruvat Transaminase)en_US
dc.titleEFEK HEPATOPROTEKTIF EKSTRAK JAMUR LINGZHI (Ganoderma lucidum) PADA TIKUS TERINDUKSI PARASETAMOLen_US
dc.typeThesisen_US


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