Show simple item record

Pengaruh Pemberian Ekstrak Etanol Meniran (Phyllanthus Niruri L) Selama 90 Hari terhadap Fungsi Hati Tikus

dc.contributor.authorSujono, Tanti Azizah
dc.contributor.authorWahyuni, Arifah Sri
dc.contributor.authorDa’i, Muhammad
dc.contributor.authorTrisharyanti, Ika
dc.contributor.authorKusumowati, Diah
dc.date.accessioned2015-02-03T06:51:11Z
dc.date.available2015-02-03T06:51:11Z
dc.date.issued2015-01-24
dc.identifier.citation1. Aslam, M. Tan, C.K. dan Prayitno, A. 2003. Farmasi Klinis: Menuju Pengobatan Rasional dan Penghargaan Pilihan Pasien. PT Elex Media Komputindo Kelompok Gramedia. Jakarta. Hal. 155, 156, 157-158. 2. Bagalkotkar, G. Sagineedu, S.R. Saad, M.S. and Stanslas, J. 2006. Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review. Journal of Pharmacy and Pharmacology, 58 (12) : 1559-1570. 3. Chatterjee, M. and Sil, P.C. 2006, Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo, Indian J.Biochem Biophys, 43(5):299-305. 4. Dai, M. dkk. 2014. Pemanfaatan antioksidan alami pada upaya pencegahan komplikasi akibat stres oksidatif pada tikus yang diinduksi diabetes melitus, Laporan Penelitian INPRU. 5. Donatus, I.A. 2001. Toksikologi Dasar, Laboratorium Farmakologi dan Toksikologi. Fakultas Farmasi. UGM. Yogyakarta 6. Hayes, M.A., 2007. Pathophysiology of the Liver. Saunder Company. USA. 7. Hushada, Y. 1996. Fisiologi dan Pemeriksaan Biokimia Hati. 11. Dalam Syaiffoelloh N. (Editor Kepala). Buku Ajar Ilmu Penyakit Dalam. Edisi III. Jilid I. Balai Penerbit Fakultas Kedokteran Universitas Indonesia, Jakarta. Hal. 224-226. 8. Kardinan, A. dan Kusuma, F.R. 2004. Meniran Penambah Daya Tahan Tubuh Alami. Jakarta: Agromedia Pustaka. 9. Lu, F.C. 1995. Toksikologi Dasar: Asas, Organ Sasaran dan Penilaian Resiko. Diterjemahkan oleh Nugroho, E. Edisi Kedua. Universitas Indonesia Press, Jakarta. Hal. 208, 210, 216-217 10. Mitruka, B.M., and H.M. Rawnsley, 1981, Clinical Biochemical and Hematological. Reference Values in Normal Experimental Animals and Normal Humans, Masson Publishing USA. Inc. 11. Muchayat, S., 2004, Fibronectine Serum sebagai Biomarker Prediktor Fibrosis pada Penderita kronik Hepatitis dan Serosis Hati, (Online), (http://www.lisaira@litbang.depkes.go.id /jkpkbbk-gdl-res-2004-muchayat2c-2130fibrosis, diakses 10 Desember 2014). 12. Naaz, F. Javed, S. And Abdin, M.Z. 2007. Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn on Aflatoxin B1induced liver damage in mice, Journal oEthnopharmacology, 113 (3):503-509 13. Price S.A. and Wilson L.M. 2006.Patofisiologi Konsep Klinis Prosesproses Penyakit, Edisi VI. Volume IJakarta: EGC. 14. Rosen, P., Tritschler, H.J., and Packer, L., 2002, Vascular Complications in Diabetes : Mechanisms and the Influence of Antioxidans, 511-524, in Handbook of Antioxidants, second edition Revised and Expanded, edited by Enrique Cadenas and Lester Packer, New York. 15. Saraswati, N.F. 2012, Profil kandungan senyawa dan aktivitas penangkap radikal DPPH fraksi-fraksi ekstrak herba meniran (Phyllanthus niruri L), Skripsi, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia. 16. Scott, J.A. and King, G.L. 2004, Oxidative Stress and Antioxidant Treatment in Diabetes, Ann.N.Y. Acad. Sci. 1031 : 204-213, New York. 17. Shetti, A.A. Sanakal, R.D. & Kaliwal, B.B. 2012 Diabetic effect of ethanolic leaf extract of Phyllanthus amarus in alloxan induced diabetic mice, Asian Journal of Plant Science and Research. 2 (1), 11-15. 18. Sumardi, M. 2010. Efek meniran (Phyllanthus niruri L) terhadap kadar AST dan ALT mencit BABL/C yang diinduksi asetaminofen. Skripsi. Fakultas kedokteran. Universitas Diponegoro. Indonesia. 19. Surya, A.E. 2014. Uji antioksidan ekstrak meniran (Phyllanthus niruri L.) pada tikus Sprague Dawley yang diinduksi parasetamol. Skripsi. Fakultas Farmasi Universitas Muhammadiyah Surakarta. 20. Underwood, J.C.E. 2000. Patologi Umum dan Sistemik. Vol.2. 2 nd ed. Jakarta. EGC. 21. Zimmerman, H.J. 1978. Hepatotoxicity. Appleton Century Croftts, New York. p. 46-51. 95-101, 103-110 225-227en_US
dc.identifier.issn2407-9189
dc.identifier.urihttp://hdl.handle.net/11617/5164
dc.description.abstractPreliminary research showed that meniran herbs (Phyllanthus niruri L.) had various biological activities such as anticarcinogen, hepatoprotective, antioxidant. A medicinal plant to be developed into a standardized herbal medicine, it is needed safety test in animal (preclinic test). This study aimed to evaluate the influence of ethanolic extract of meniran on liver function in rats given for the long term. A total of 36 male and female rats were divided into 3 groups: control (aquadest), ethanolic extract of meniran with dose 50 mg/kgbw and 250 mg/kgbw, each group consisted of 6 rats. Treatment was given with repeated doses for 90 days. To evaluate the liver function, there were 2 parameters: quantitative and qualitative data. The quantitative data include SGPT (serum glutamate piruvate transaminase) and SGOT (serum glutamate oxaloacetate transaminase) and qualitative data was histopathology of liver. SGPT and SGOT level were measured on days 0, and 90. SGPT and SGOT level were compared between before and after treatment using paired t test with a 95% confidence level. Data of histopathology compared to the control group. The results showed that the ethanolic extract of meniran dose 50 and 250 mg/kg body weight administered repeatedly for 90 days had no toxic effect on liver function of male and female rats.en_US
dc.publisherUniversitas Muhammadiyah Surakartaen_US
dc.subjectPhyllanthus niruri Len_US
dc.subject90 daysen_US
dc.subjectSGPTen_US
dc.subjectSGOTen_US
dc.subjecthistopathologyen_US
dc.titlePengaruh Pemberian Ekstrak Etanol Meniran (Phyllanthus Niruri L) Selama 90 Hari terhadap Fungsi Hati Tikusen_US
dc.typeArticleen_US


Files in this item

Thumbnail
Name:
15.Tanti Azizah Sujono.pdf
Size:
569.0Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record