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| dc.description.abstract | Some anti tuberculosis drugs were used in combination to treat tuberculosis. Appropriate therapy shows good
outcome, however, anti tuberculosis drugs can cause hepatotoxicity. The previous study suggests that malnutrition is a
risk factor of Drug Induced-Hepatitis (DIH). Objective of this study was to determine whether moderate malnutrition is a
risk factor of DIH among children treated with anti-tuberculosis drugs. In this study, a case-control study was conducted
among children treated with anti-tuberculosis drugs. Data were obtained from medical record of outpatient and inpatient
of pediatrics patients from January 2001 to November 2006 in 6 hospitals. DIH is defined as elevated serum transaminase 5
times more than normal, elevated bilirubin level more than 1,5 mg/dl or any elevation of transaminase serum with clinical
symptom such as icteric. Patients meeting the inclusion criteria were included in the study and those meeting the
exclusion criteria excluded from the study. Then data were followed retrospectively to see the nutritional status at the
starting point of therapy. The Odds Ratio (OR) of nutritional status determine using chi square analysis. There were 31
children diagnosed as DIH, 2 were excluded from the study because of phenytoin and carbamazepin therapy. There were
no significant differences on age, gender, and moderate malnutrition. Only severe malnutrition was had significant
difference with OR 3,2 (95% CI 1,13 9,2; p = 0,023). Malnutrition is not a risk factor while severe malnutrition is a risk factor
of DIH among children treated with anti tuberculosis drugs. | en_US |
