| dc.contributor.author | Saifulhaq M., M. | |
| dc.date.accessioned | 2012-03-16T06:23:36Z | |
| dc.date.available | 2012-03-16T06:23:36Z | |
| dc.date.issued | 2009-02 | |
| dc.identifier.citation | Abbas A, Lichtman AH, Pober JS. 1997. Antigen presentation and cell antigen recognition. In: Cellular and molecular immunology. 3rd ed. WB Saunders. Philadelphia. P. 116-35. Baratawidjaja K. 2000. Imunologi dasar. Ed 4. Balai Penerbit Fakultas Kedokteran Universitas Indonesia. Jakarta Hartati MS, Mubarika S, Gandjar IG, Hamann MT, Rao KV, Wahyuono S. 2005. Phalerin, a new benzophenoic glucoside isolated from the methanol ectract of mahkota dewa [Phaleria macrocarpa (Scheff ). Boerl.] leaves. Majalah farmasi Indonesia.15 Jiao Y, Wen J, Yux. Influence of flavanoid of Astragalus membranaceus's stam and leaves on the function of cell mediated immunity in mice. Available at: URL:http://www.ncbi.nlm.nih.gov/pubmed.Accessed Juny 20, 2003 Lisdawati V. Buah mahkota dewa (Phaleria macrocarpa (Scheff) Boerl.) toksisitas, efek antioksidan dan efekantikanker berdasarkan uji penapisan farmakologi. From : http://www.mahkotadewa.com/VPC/vivi.htm. Diakses 20 Oktober 2002 Middleton E, Kandaswami C, Theoharides TC. 2000. The effects of plant flavonoids on mammalian cells:implications for inflammation, heart disease, and cancer. Pharmacological Reviews.52 (4): 673-751 Sepgana S, Iwang S, Ganthina. 1988. Skrining fitokimia dan asam fenolat daun dewa/Gynura procumbens (Lour.) merr. Simposium penelitian Tumbuhan obat III, Universitas Indonesia, Jakarta. Sumastuti R, M Sonlimar. Efek sitotoksik ekstrak buah dan daun mahkota dewa [Phaleria macrocarpa (Sceff) Boerl.] terhadap sel hela. Available at: URL:http://www.tempointeraktif.com/medika/online/i ndex-isi.asp?file=art-3. Diakses 20 Juni 2003 Weir DM. 1990. Segi praktis imunologi. Alih Bahasa: Suryawidjaja, JE. Cetakan 1. Binarupa Aksara. Jakarta Winarto W.P. 2003. Mahkota dewa budi daya dan pemanfaatan untuk obat. Penebar Swadaya. Jakarta | en_US |
| dc.identifier.issn | 2085-8345 | |
| dc.identifier.uri | http://hdl.handle.net/11617/530 | |
| dc.description.abstract | Mahkota dewa (Phaleria papuana) fruits consists of chemicals that are able to increase lymphocytes
proliferation. The objective of this study was to show the influence of Mahkota dewa's fruits extract in spleen
lymphocytes proliferation of BALB/C mice. An experimental study with the post-test only control group design was
carried out on experiment animal BALB/C mice, consisted of 25 male mice which devided into 5 groups. K was
control group without treatment with mahkota dewa extract, whereas P1 was group treated with mahkota dewa
extract 0,2 ml/day (± 35 ìg extract). P2 was group given mahkota dewa extract 0,4 ml/day (± 70 ìg extract), P3 was
group given mahkota dewa extract 0,8 ml/day (± 140 ìg extract), and P4 was group given mahkota dewa extract 1,5
ml/day (± 280 ìg extract). Lymphocytes from the spleen of all mice were isolated after 2 weeks treating.
Lymphoblasts were counted in every 200 cells. There were significant differences in lymphoblasts count between K
and P1 (p=0,009), K and P2 (p=0,028), P1 and P2 (p=0,009), P1 and P3 (p=0,009), P1 and P4 (p=0,009), P2 and P3
(p=0,012), P2 and P4 (p=0,028). And there were no significant differences in lymphoblasts count between K and P3
(p=0,917), K and P4 (p=0,675), P3 and P4 (p=0,917). On the giving of mahkota dewa's fruits extract there were
significant increase of lymphocyte proliferations on BALB/C mice on P1 and P2 groups. But there were not on P3 and
P4 ones. | en_US |
| dc.subject | lymphocyte proliferation | en_US |
| dc.subject | mahkota dewa | en_US |
| dc.title | Pengaruh Pemberian Ekstrak Buah Mahkota Dewa Dosis Bertingkat Terhadap Proliferasi Limfosit Lien pada Mencit BALB/C | en_US |
| dc.type | Article | en_US |
