Show simple item record

dc.contributor.authorMardiyanto
dc.date.accessioned2015-10-30T07:21:06Z
dc.date.available2015-10-30T07:21:06Z
dc.date.issued2015-10-30
dc.identifier.citation[1] Karyadi, E., W. Schultink, "Poor micronutrient status of active pulmonary tuberculosis patients in Indonesia". Nutrition, 2000. 130(12). pp 2953-2958. [2] Moghazeh, S. L., X. I. Pan,. "Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations" Antimicrobial Agents, 1996, 40(11). pp 2655-2657. [3] Walters, S. B. and B. A. Hanna, "Testing of susceptibility of Mycobacterium tuberculosis to isoniazid and rifampin by mycobacterium growth indicator tube method" Clin Microb. 1996, 34(6). pp 1565-1567. [4] Barichello, J.M., Morishita, M., Takayama, K., and Nagai, T., "Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method" Drug Dev Ind Pharm, 1999. 25(4). pp 471-476. [5] Jain, R.A., "The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomater", 2000. 21(23). pp 2475-2490. [6] Ravi Kumar, M.N., Bakowsky, U., and Lehr, C.M., "Preparation and characterization of cationic PLGA nanospheres as DNA carriers" Biomater, 2004. 25(10). pp 1771-1777. [7] Astete, C.E. and Sabliov, C.M., "Synthesis and characterization of PLGA nanoparticles" J Biomater Sci Polym Ed, 2006. 17(3). pp 247-289. [8] Bala, I., Hariharan, S., and Kumar, M.N., "PLGA nanoparticles in drug delivery: the state of the art" Crit Rev Drug Carrier Syst, 2004. 21(5). pp 387-393. [9] Cohen-Sela, E., Chorny, M., Koroukhov, N., Danenberg, H.D., and Golomb, G., A new double emulsion solvent diffusion technique for encapsulating hydrophilic molecules in PLGA nanoparticles. J Controlled Release, 2009. 133(2). pp 90-95. [10] Kawashima, Y., Yamamoto, H., Takeuchi, H., Hino, T., and Niwa, T., Properties of a peptide containing DL-lactide/glycolide copolymer nanospheres prepared by novel emulsion solvent diffusion methods. Eur J Pharm Biopharm, 1998. 45(1). pp 41-48. [11] Niwa, T., Takeuchi, H., Hino, T., Kunou, N., and Kawashima, Y., "In vitro drug release behavior of D,L-lactide/glycolide copolymer (PLGA) nanospheres with nafarelin acetate prepared by a novel spontaneous emulsification solvent diffusion method" J Pharm Sci, 1994. 83(5). pp 727-32. [12] Mardiyanto and Neuert Achim, "Development of Particulate Formulation, Loading, Procedure, and Nanoscale Charachterization of PLGA Nanoparticles Incorporating Root Extract of Pueraria lobata (wild) Ohwl". Proceed. ICB Pharma, 2015, 1(1). pp 10-16.in_ID
dc.identifier.issn9-772476-969006
dc.identifier.urihttp://hdl.handle.net/11617/6202
dc.description.abstractThe research had been performed to incorporate rifampin into PLGA submicron-sized particles. This research has a prospect to be applied to overcome the ineffectiveness use of rifampin for tuberculosis patients as rifampin was not stable in human lung macrophages, while Mycobacterium tuberculosis was able to survive in human lung macrophages. Rifampin was incorporated into submicron particles of PLGAs using the emulsion solvent diffusion method. The use of rifampin 50 mg in every batch resulted in the submicron-sized particles of 220 nm, PDI 0:12, zeta potential 21 mV and EE 37%. In the batch using rifampin 300 mg, resulted the submicron-sized particles of 410 nm, PDI 0:22, zeta potential 14 mV and EE 40%. The surface of the particles was visualized by SEM and hydrodynamic size compared to TEM. It was known that particle is spherical with a smaller diameter than the hydrodynamic size. TEM measurement revealed the size of particles with PVA was 208 nm.in_ID
dc.language.isoenin_ID
dc.publisherUniversitas Muhammadiyah Surakartain_ID
dc.subjectcharacterizationin_ID
dc.subjectPLGAin_ID
dc.subjectrifampinin_ID
dc.subjecthydrodynamic-sizein_ID
dc.subjectTEMin_ID
dc.subject%EEin_ID
dc.titlePreparation and Characterization of Submicron Particles of PLGA Incorporating Rifampin Using Emulsion Solvent Diffusion Methodin_ID
dc.typeArticlein_ID


Files in this item

Thumbnail

This item appears in the following Collection(s)

  • ICB-PHARMA II
    Current Breakthrough in Pharmacy Materials and Analyses

Show simple item record