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Uji Toksisitas Akut dari Ekstrak Kulit Buah Rambutan (Nephelium Lappaceum L.) yang Berpotensi Sebagai Obat Herbal Antidiabetes

dc.contributor.authorMuhtadi, Muhtadi
dc.contributor.authorHaryoto, Haryoto
dc.contributor.authorSujono, Tanti Azizah
dc.contributor.authorSuhendi, Andi
dc.date.accessioned2015-11-16T03:36:25Z
dc.date.available2015-11-16T03:36:25Z
dc.date.issued2015-08-29
dc.identifier.citationAnnida, R., 2011, Korelasi Aktivitas Antioksidan Dengan Kadar Fenolik dan Flavonoid Total Ekstrak Etanol Kulit dan Biji Kelengkeng Total (Euphorbia longan Lour. Steud) Beserta Fraksi-Fraksinya, Skripsi, Universitas Muhammadiyah Surakarta. Batubara, R. W., 2011, Uji Aktivitas Antioksidan Ekstrak Etanol Kulit Buah Durian (Durio zibethinus Murr) Lokal dan Fraksi-Fraksinya Dengan Metode DPPH Serta Penetapan Kadar Fenolik dan Flavonoid Totalnya, Skripsi, Surakarta, Fakultas Farmasi Universitas Muhammadiyah Surakarta. Dalimartha, S., 2003, Atlas Tumbuhan Obat Indonesia, Jilid 2, Jakarta, Puspa Swara. Depkes, 2005, Pharmaceutical Care Untuk Penyakit Diabetes Melitus, Jakarta, Departemen Kesehatan RI. Haruenkeit, R., Poovarodom, S., Vearasilp, S., et al., 2010, Comparison of Bioactive Compounds, Antioxidant and Antiproliferative Activities of Mon Thong Durian During Ripening, Food Chemistry, 118(3), 540-547. Khasanah, A.N., 2011, Uji Aktivtas Penangkap Radikal Bebas Ekstrak Etanol, Fraksi- Fraksinya Dari Kulit Buah Dan Biji Rambutan (Nephelium lappaceum L.) Serta Penetapan Kadar Fenolik Dan Flavonoid Totalnya, Skripsi, Universitas Muhammadiyah Surakarta Kumar, E. K., Ramesh, A., and Kasiviswanath, R., 2005, Hypoglicemic and Antihyperglicemic Effect of Gmelina asiatica Linn. in Normal and in Alloxan Induced Diabetic Rats, Biol. Pharm. Bull. 28(4), 729-732. Leontowicz, H., Maria, L., Iwona, J., et al., 2011, Positive Effects of Durian Fruit At Different Stages of Longan (Dimocarpus longan) Ripening On The Hearts and Livers of Rats Fed Diets High in Cholesterol, European Journal of Integrative Medicine, 3, 169-181. Loomis,T., 1978. Essential of Toxicology, 3rd edition, Lea & Febriger, Philadelphia. Manaharan, T., Palanisamy, U. D., and Ming, C. H., 2012, Tropical Plant Extracts as Potential Antihyperglycemic Agents, Molecules 17(5), 5915-5923. Muhtadi, Haryoto, Sujono, T.A., Suhendi, A., Yen, K.H., 2014, Antioxidant and Chemical Constituents of Some Indonesian Fruit Peels, Medicinal Plants – International Journal of Phytomedicines and Related Industries, 6(1), 43-46. Muhtadi, Primarianti, A.P., Sujono, T.A., 2015, Antidiabetic Activity of Durian (Durio zibethinus Murr.) and Rambutan (Nephelium lappaceum L.) Fruit Peels in Alloxan Diabetic Rats, Procedia Food Science, 3 (2015), 255-261. Palanisamy, U. D., Ling, L. T., Manaharan T., Appleton, D., 2011, Rapid Isolation of Geraniin From Nephelium lappaceum Rind Waste and it’s Anti-Hyperglycemic activity, Food Chemistry 127, 21–27. Tabata, H., Katsube, T., Tsuma, T., Ohta, Y.,, Imawaka, N., dan Utsumi, T., 2008, Isolation and evaluation of the radical-scavenging activity of the antioxidants in the leaves of an edible plant Mallotus japonicus, Food Chemistry, 109(1), 64-71. Tamimiy, 2006, Aktivitas Antioksidan Ekstrak Etanol Kulit Buah Rambutan (Nephellium lappaceum L.) Terhadap Peredaman Radikal Bebas DPPH Secara Spektrofotometri, Yogyakarta. Waltner-Law M, E., Wang X, L., Law B, K., Hall R, K., Nawano, M., 2002, Epigallocatechin gallate, a constituent of Green tea represses hepatic glucose production, J. Bio. Chem., 277(38), 34933–34940. WHO, 1999, Definition, Diagnosis and Classification od Diabetes Melitus and it’s Complications, Geneva, World Health Organization Department on Noncommunicable Disease Surveillance. Wijiastuti, L., 2011, Aktivitas Antibakteri Ekstrak Etanol Kulit Buah Jeruk Manis (Citrus sinensis (l.) osbeck) terhadap Staphylococcus aureus dan Escherichia coli multiresisten serta Brine Shrimp Lethality Test, Skripsi, Universitas Muhammadiyah Surakarta.in_ID
dc.identifier.issn2407-9189
dc.identifier.urihttp://hdl.handle.net/11617/6274
dc.description.abstractThe acute toxicity testing have been conducted in the male and female rats SD strain of rambutan (Nephelium lappaceum L.) fruit peel extract. The testing had been done by providing with a dose ranked as follows: the first dose; 0 mg / kgBW, dose II; 400 mg / kgBW, dose III; 1,400 mg / kgBW, IV doses; 4,900 mg / kgBW, and the dosage of V; 17,150 mg / kgBW for 14 days. Then it had been observed clinical symptoms that happened, changed in body weight per week and defect on vital organs, namely: the liver, kidneys, stomach, intestines, spleen, heart and lungs. The results of this study was concluded that the highest dose of up to 17,150 mg / kgBW of the extract, safety and proved to be not toxic to the female and male rats SD strain.in_ID
dc.language.isoidin_ID
dc.publisherUniversitas Muhammadiyah Surakartain_ID
dc.subjectThe acute toxicity testingin_ID
dc.subjectrambutan fruit peel extractin_ID
dc.subjectthe female and male rats SD strainin_ID
dc.titleUji Toksisitas Akut dari Ekstrak Kulit Buah Rambutan (Nephelium Lappaceum L.) yang Berpotensi Sebagai Obat Herbal Antidiabetesin_ID
dc.typeArticlein_ID


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