Antihyperuricemia Preclinical Testing and Standardized Extracts Of Salam (Syzigium polyanthum Walp.) and Belimbing Wuluh (Averrhoa bilimbi Linn.) Leaves

Abstract

Antihiyperuricemia activity testing had been carried out in vivo from a single and combination of extracts from Salam (Syzigium polyanthum Walp) and Belimbing wuluh (Averrhoa bilimbi L.). Dried extracts of each herbs had been done antihiyperuricemia preclinical testing in vivo on male white mice Balb-C strain induced by potassium oxonic dose of 250 mg/kg. The results of antihyperuricemia preclinical testing showed that extracts of salam and belimbing wuluh leaves, single dose of 200 mg/kg had lower activity levels of uric acid in blood serum of mice, respectively, 0.64 and 0.68 mg/dL. While antihyperuricemia activity of a combination of salam-belimbing wuluh extracts is 1.380. Each of the extracts had been analyzed for standardization extracts with the test procedure based on the parameters of Materia Medica Indonesia and the general standardize of medicinal plant extracts suggested by BPOM RI, which include non-specific and specific parameters. Overall, based on the results of standard tests common medicinal plant extracts, the two materials under study had met the recommended requirements.