Antihypercholesterol Activity Of Ethanol Extracts Of Durian (Durio zibethinus Murr) and Longan (Euphoria longan Lamk) Fruit Peels on Male White Rats Wistar Strain

Abstract

Durian (Durio zibethinus Murr) and longan (Euphoria longan Lamk) fruit peels contain flavonoid compounds that might have potential activity as antihypercholesterol. The purpose of this study to determine the antihypercholesterol effect of ethanol extract of durian and longan fruit peels on the white rats Wistar strain. The research method is the pre and post control group design. Fourty rats were divided to 8 treatment groups. Group I (negative control) were given CMC-Na 0,5%, group II (positive control) were given Colestiramine 0,8 g/kgBW, group III, IV, V, VI, VII and VIII treated by ethanol extract of durian and longan fruit peels with consecutive doses 125, 250, and 500 mg/kgBW. Before treatment, the rats were given high cholesterol diets and fed diets supplemented with cholesterol during 4 weeks. The composition of high cholesterol diets were cooking oil, quail egg yolk, water, PTU (Propyltiourasil) and fed diets supplemented with cholesterol were margarine, quail egg yolk, standard feed. The treatment of antihypercholesterol testing on the rats conducted for 2 weeks. The result showed that durian and longan fruit peels ethanol extracts have potential antihypercholesterol activity. Percentage decreasing of cholesterol total level of ethanol extract of durian and longan fruit peels with consecutive doses 150, 250, and 500 mg/kgBW were 12.56%, 35.79%, 35.82%, 27.61%, 33.56%, 33,97%, respectively. While Colestiramine 0.8 g/kgBW as a positive control had value decreasing percentage of total cholesterol was 34.20%