Sintesis Senyawa Kalkon (E)-1-(4-Klorofenil)-3-P-Tolilprop-2-En-1-On dan Uji Toksisitasnya
| dc.contributor.author | Brahmana, Eti Meirina | |
| dc.date.accessioned | 2016-11-03T05:57:46Z | |
| dc.date.available | 2016-11-03T05:57:46Z | |
| dc.date.issued | 2016-05-21 | |
| dc.identifier.citation | Achanta, G,. Modzelewska, A., Feng, L,. Khan, S.R,. & Huang, P., 2006, Boronic chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome, Molecular pharmacol, 70. 426-433. Choudhary, A.N., & Juyal, V. 2011. Synthesis of chalcone and their derivates as antimicrobial agents. International journal of pharmacy and pharmaceutical Sciences, 3(3): 125-128. Echeverria, C., Santibanez, J.F., Tauda, O.D, Escobar, C.A., & Tagle, R.R, 2009, Structural antitumoral activity relationships of synthetic chalcones. International journal of molecular sciences 10: 221-231. Jayapal, M.R., & Sreedhar, N.Y. 2011. Synthesis and Characterization of 2,5-Dihydroxy Substituted Chalcones Using SOCl2/EtOH. International Journal of Pharmacy and Pharmaceutical Sciences. 3(1): 127-129. Jayapal, MR, K.S. Prasad, & Sreedhar, N.Y., 2010, Synthesis and characterization of 2,5-dihydroxy substituted chalcones using Socl2/Etoh, Int j pharma bio sci 1 : 361-6. Kakati, D., & Sarma ,J.C. 2011. Microwave Assisted Solvent Free Synthesis of 1,3-Diphenylpropenones. Chemistry Central Journal. 5(8): 1-5. Meyer, B.N.R., Ferrigni, J.E., Putnam, L.B., Jacosen, D.E., Nicholas., & McLaughin, J.L. 1982, Brine Shrimp: A convenient general bioassay for active plant constituens. Planta Med, 45, 31-34. | in_ID |
| dc.identifier.issn | 2557-533X | |
| dc.identifier.uri | http://hdl.handle.net/11617/7935 | |
| dc.description.abstract | Halogen substituted analogoues compounds chalcone, (E)-1-(4-klorofenil)-3-p-tolilprop-2-en-1-on, was synthesized from 4-metyl benzaldehyde as aldehydes with 4-chloroacetophenone as ketones by using aldol condensation reaction. The compound resulted rendement with value of 87,51% and characterized by using UV, IR, MS, and 1 HNMR. Toxicity tests using Brine Shrimp Lethality Test (BSLT) showed that those compounds have a potency as anticancer agent with LC50 value 39,8 µg/mL | in_ID |
| dc.language.iso | id | in_ID |
| dc.publisher | Universitas Muhammadiyah Surakarta | in_ID |
| dc.subject | Chalcone | in_ID |
| dc.subject | halogen | in_ID |
| dc.subject | toxicity tests | in_ID |
| dc.title | Sintesis Senyawa Kalkon (E)-1-(4-Klorofenil)-3-P-Tolilprop-2-En-1-On dan Uji Toksisitasnya | in_ID |
| dc.type | Article | in_ID |
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