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dc.contributor.authorSari, Wening
dc.date.accessioned2020-01-22T02:09:38Z
dc.date.available2020-01-22T02:09:38Z
dc.date.issued2019
dc.identifier.citationAdiwinata, R., Kristanto, A., Christianty, F., Richard, T., & Edbert, D. (2015). Tatalaksana Terkini Perlemakan Hati Non-Alkoholik, 2(1), 53–59. Ann, J., Eo, H., & Yunsook, L. (2015). Mulberry leaves ( Morus alba L .) ameliorate obesityinduced hepatic lipogenesis , fibrosis , and oxidative stress in high-fat diet-fed mice. Genes & Nutrition, 10(6), 1–13. https://doi.org/10.1007/s12263-015-0495-x Arab, J. P., Arrese, M., & Trauner, M. (2018). Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease. Annu. Rev. Pathol. Mech. Dis, 13, 321–50. Retrieved from http;//doi. org/10.1146/annurev-pathol-020117-043617 Ayokanmi, O., & Akinloye, O. A. (2019). Oxidative Stress and Antioxidant Biomarkers in Clinical and Experimental Models of Non-Alcoholic. Medicina, 55(26). https://doi.org/10.3390/ medicina55020026 Buzzetti, E., Pinzani, M., & Tsochatzis, E. A. (2016). The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism, 65(8), 1038–1048. https://doi.org/10.1016/j. metabol.2015.12.012 Chan, E. W., Lye, P., & Wong, S. (2016). Phytochemistry , pharmacology , and clinical trials of Morus alba. Chinese Journal of Natural Medicines, 14(1), 17–30. https://doi.org/10.3724/ SP.J.1009.2016.00017 Cobbina, E., & Akhlaghi, F. (2017). Non-Alcoholic Fatty Liver Disease (NAFLD) - Pathogenesis, Classification, and Effect on Drug Metabolizing Enzymes and Transporters. Drug Metab Rev, 49(2), 197–211. https://doi.org/10.1080/03602532.2017.1293683.Non-Alcoholic Deeb, A., Attia, S., Mahmoud, S., Elhaj, G., & Elfatih, A. (2018). Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children, 2018. https://doi.org/10.1155/2018/8626818 Iqbal, U., Perumpail, B. J., John, N., Sallam, S., Shah, N. D., Kwong, W., Ahmed, A. (2018). Judicious Use of Lipid Lowering Agents in the Management of NAFLD. Diseases, 6(87), 1–10. https://doi.org/10.3390/diseases6040087 Kasim, S., Arief, M., Sulaeman, A., & Widodo, J. (2012). Hubungan Obesitas dan Hipertrigliseridemia dengan Risiko Perlemakan Hati pada Pasien di Makassar Relationship between Obesity and Hypertriglyceridemia on Fatty Liver in Patients at Makassar, 1, 136–146. Katsiki, N., Mikhailidis, D. P., & Mantzoros, C. S. (2016). Non-alcoholic fatty liver disease and dyslipidemia: an update. Metabolism, 65(8), 1109–23. https://doi.org/10.1016/j. metabol.2016.05.003 Kobayashi, Y., Miyazawa, M., Araki, M., Kamei, A., Abe, K., Hiroi, T., … Kojima, T. (2016). Pharmacognosy & Natural Products Effects of Morus alba L . ( Mulberry ) Leaf Extract in Hypercholesterolemic Mice on Suppression of Cholesterol Synthesis. J Pharmacogn Nat Prod, 2(1), 1–9. https://doi.org/10.4172/2472-0992.1000113 Kutlu, O., Kaleli, H. N., & Ozer, E. (2018). Molecular Pathogenesis of Nonalcoholic Steatohepatitis- ( NASH- ) Related Hepatocellular Carcinoma, 2018. Lieber, C. S., Leo, M. A., Mak, K. M., Xu, Y., Cao, Q., Ren, C., Decarli, L. M. (2004). Model of non-alcoholic steatohepatitis. American Journal of Clinical Nutrition, 79(March 2018), 502–9. https://doi.org/10.1093/ajcn/79.3.502 Metwally, F. M., Ahmed, H. H., Rashad, H., & Zaazaa, A. M. (2016). Insights into the role of morus alba in reversing obesity-associated hepatic steatosis and related metabolic disorder in rats. Asian J Pharm Clin Res, 9(Supp 2), 231–8. Park, E., Lee, S., Lee, J., & Kim, J. (2012). Anti-inflammatory activity of mulberry leaf extract through inhibition of NF- j B. Journal of Functional Foods, 5(1), 178–186. https://doi. org/10.1016/j.jff.2012.10.002 Peng, C., Lin, H., Chung, D., Huang, C., & Wang, C. (2017). ScienceDirect Mulberry Leaf Extracts prevent obesity-induced NAFLD with regulating adipocytokines , inflammation and oxidative stress. Journal of Food and Drug Analysis, 26(2), 778–787. https://doi.org/10.1016/j. jfda.2017.10.008 Rodrigues, E. L., Marcelino, G., Silva, G. T., Figueiredo, P. S., Garcez, W. S., Corsino, J.,C, K. De. (2019). Nutraceutical and Medicinal Potential of the Morus Species in Metabolic Dysfunctions. https://doi.org/10.3390/ijms20020301 Syafitri, V., Arnelis, & Efrida. (2015). Artikel Penelitian Gambaran Profil Lipid Pasien Perlemakan Hati Non-Alkoholik. Jurnal Kesehatan Andalas, 4(1), 274–278. Xia, M., Bian, H., & Gao, X. (2019). NAFLD and Diabetes : Two Sides of the Same Coin ? Rationale for Gene-Based Personalized NAFLD Treatment, 10(August), 1–11. https://doi. org/10.3389/fphar.2019.00877 Yu, J., Marsh, S., Hu, J., Feng, W., & Wu, C. (2016). The Pathogenesis of Nonalcoholic Fatty Liver Disease : Interplay between Diet , Gut Microbiota , and Genetic Background, 2016. Zeni, A. L. B., & Molin, M. D. (2010). Artigo Hypotriglyceridemic effect of Morus alba L ., Moraceae , leaves in hyperlipidemic rats, 20(October 2008), 130–133.id_ID
dc.identifier.issn2615-1588
dc.identifier.urihttp://hdl.handle.net/11617/11823
dc.description.abstractNon Alcoholic steatohepatitis (NASH) is associated with the inflammation of fatty liver due to insulin resistance, dyslipidemia and oxidative stress. Treatment of NASH focused on control metabolic disorder and minimizes oxidative stress. White mulberry (Morus alba Linn) leaf has been reported for its anti-cholesterol and antioxidant effect. This study focused on effects of ethanolic extracts of white mulberry (EEM) leaf to total cholesterol, triglycerides and malondialdehyde (MDA) level of a high-fat diet induced steatohepatitis in rats. The experimental animals, male Wistar strain rats, divided into 5 groups. The rats fed high-fat diet to induced NASH and treated by 90, 180 and 360 mg/bodyweight/day of EEM for 21 successive days. The remaining 2 groups served as control, they fed standard and high-fat diet only. At the end of treatment all subjects were sacrificed using decapitation method. Blood was collected and measured for total cholesterol and triglycerides (Randox). Liver tissue was collected for MDA measurement and histopathologic preparation using haematoxylin-eosin staining. MDA level was measured using thiobarbituric acid reactive-substances (TBARS) method for oxidative stress measurement. EEM treatment significantly reduce cholesterol, triglycerides, and MDA levels as compared with high-fat diet control group (p<0.05). This result in line with histopathological finding as indicated by relatively mild hepatocytes cellular damage. It was conclude that EEM might prevent hyperlipidemia and oxidative stress-induced steatohepatitis.id_ID
dc.language.isootherid_ID
dc.publisherISETH 2019 (International Summit on Science, Technology, and Humanity)id_ID
dc.titleEthanolic Extracts of Mulberry (Morus alba Linn) Leaf Prevent Hyperlipidemia and Oxidative Stress-induced Steatohepatitis in Ratsid_ID
dc.typeArticleid_ID


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