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dc.contributor.authorSusilo, Jatmiko
dc.contributor.authorPurnama, Siswanta Jaka
dc.contributor.authorWahyuni, Ardianti
dc.contributor.authorPurwanto, Bambang
dc.contributor.authorDoewes, Muchsin
dc.contributor.authorIndarto, Dono
dc.date.accessioned2020-01-22T02:37:20Z
dc.date.available2020-01-22T02:37:20Z
dc.date.issued2019
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Nephrol Dial Transplant.;24:130–136. doi: 10.1093/ndt/gfn420 Polsjak B, Suput, D., Milisave, I., (2013), Review Article : Achieving between ROS and antioxidant, when use the synthetic antioxidant, J Oxid Med and Cell Longevity, : 1-11. Preminger G.M, and Curhan G.C., (2009), Patient information: Kidney Stones in adults.. Up to date online. http://www.uptodate.com/patients/content/topic.do? Repetto M., Semprine, J., a n d Boveris, A., (2012), Lipid Peroxidation: Chemical Mechanism, Biological Implications and Analytical Determination, Intech Pub., 3-25, http://dx.doi. org/10.5772/45943 Scale, C.D. Jr., Smith, A.C., Hanley, J.M., and Saigal, C.S., (2012), Urologic diseases in Amarica Project, Prevalence of kidney stone in Unitated State, Eur. Urol, 621:160-165 Suhita, N.L.P.R., I.W. Sudira, dan I.B.O. Winaya. (2013). Histopatolgi ginjal tikus putih akibat pemberian ekstrak pegagan Centella asiatica peroral. Buletin Veteriner Udayana. 52:71-78. 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Herbal plants used in the treatment of urolithiasis: a review. Int. J. f Pharm. Sci. Res. 26, 1412-1420 Zuo, J., Khan, A., Glenton, P.A., and Khan, S.R., (2011). Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-Lproline- induced hyperoxaluria in the male Sprague-Dawley rats. Nephrol. Dial. Transplant 26, 1785–1796. https://doi.org/10.1093/ndt/gfr035id_ID
dc.identifier.issn2615-1588
dc.identifier.urihttp://hdl.handle.net/11617/11827
dc.description.abstractPurpose: This study was to analyze the administration of breadfruti leaf extract to changes in biochemical parameters and renal histology in hyperoxaluria rats. Methodology: The experimental study used 6 groups, each of 5 mice that are EG, Normal, Vitamin E, an ethanol extract of breadfruit 100, 200 and 400 mg/kg BW. Blood data for the analysis of biochemical parameters and kidney were taken at the end of the experiment for histological analysis of kidney changes. Results: Research shows that the purified ethanol extract of breadfruit leaf can prevent increases in MDA levels, reduce creatinine and BUN levels, increase body weight, prevent hypertrophy and kidney damage Conclusion: Purified ethanol extract of AA leaves has an antioxidant, nephroprotective activity, protect kidney inflammation, and kidney damage in nephrolithiasis rats and the effective dose is 400 mg/kg BW. The higher the extract dose, the more effective to reduce the biochemical and histopathological parameters in hyperoxaluria rats. Applications/Originality/Value: as a basis for futher studies of molecular biology in the prevention of kidney disorder.id_ID
dc.language.isootherid_ID
dc.publisherISETH 2019 (International Summit on Science, Technology, and Humanity)id_ID
dc.titleThe Biochemical and Kidney Histopathological Parameters in Hyperoxaluria Rats Treated with Breadfruit Leaf Extractid_ID
dc.typeArticleid_ID


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