| dc.identifier.citation | Carmichael, J.K. 1991. Treatment of herpes zoster and postherpetic neuralgia. Am. Family Physician 44:203-210. Corwin,E.J.,2000, Handbook of Pathophysiology, 2nd ed, Lippincott William & Wilkins, New York. 365-366 Hardman,J, 2001, Goodman& Gilman’s: The Pharmacological Basis of Theurapetics, 10th ed, Macmillan Publ. Co, London, 669-679,1531 Hoffbrand,A.V.,Pettit,J.E., and Moss, P.A.H., 2002. Kapita Selekta Hematologi, Jakarta:EGC Hoffman, P.G., M.C. Lego, and W.G. Galetto. 1983. Separation and quantitation of red pepper major heat principles by reversephase high pressure liquid chromatography. J. Agr. Food Chem. 31:1326- 1330. James, R., Privitera, M.D., and Stang Alang, M.A. 2008. Silent Clots (Penggumpalan Diam-Diam. Global Harapan Tunggal.htm (13 March 2008) Juliani, Dewi., Hernowati, T.E. 2008. Hubungan Persentase Agregasi Trombosit dengan Lamanya Konsumsi Aspirin pada Penderita Aterosklerosis di Poli Penyakit Jantung RSU Dr. Saiful Anwar Malang. Medicinus. 21. (3): 63-65 Katzung, B. G. 1993. Basic & Clinical Pharmacology. Sulistia G. Ganiswara (Eds). Farmakologi dan Terapi. Edisi IV. Jakarta: Gaya Baru Packham,M.A. and J.F. Mustard, 1971, Platelet Reactions in Disorders of Hemostatis, Grune and Stratton, New York, 30-50 Price, S.A. and Wilson, C.M. 1995. Patofisiologi Konsep Klinis Proses-Proses Penyakit. Edisi 4. Jakarta: EGC Vogel,H.G.,2002, Drug Discovery and Evaluation, Pharmacological Assays, 2 nd ed, Springer, Berlin, 280-282. | en_US |
| dc.description.abstract | Chilli pepper (Capsicum Frutescens L.) is traditional medicine, used in Indonesia for
many purposes. As a drug, it is good for the heart and blood vessels. The objective of our study was to assess the effect of aqueous extracts of dried fruits of Chilli pepper (Capsicum Frutescens L.) on bleeding time, clotting time and platelet’s amount of rats. The study was carried out on normal white rats, wistar strain. Extracts were administered orally at three doses (0.630 g/kg BW, 0.945 g/kg BW, 1.418 g/kg BW ) and acetosal was used as standard drug. All the doses of aqueous extracts of the dried fruits of chilli pepper (Capsicum Frutescens L.) used in this experiment caused a significant (p<0.05) increase in the bleeding time, clotting time and reduction of rats’ platelets’ amount compared to standard. Chilli pepper (Capsicum Frutescens L.) can influence the bleeding time and clotting time, and can reduce the platelets’ amount better than acetosal and the increased doses of the aqueous extracts have better effect. The above results showed that the aqueous extracts of the dried fruits of Chilli pepper (Capsicum Frutescens L.) has promising potential to be a drug for cardiovascular disease. | en_US |
