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dc.contributor.authorKarim, Aditya Krishar
dc.contributor.authorSismindari
dc.contributor.authorAsmara, Widya
dc.contributor.authorIstriyati
dc.date.accessioned2012-12-12T05:06:45Z
dc.date.available2012-12-12T05:06:45Z
dc.date.issued2012-06
dc.identifier.citationArunporn, I., Peter, J.H., Eno-Amooquaye, P.J., Burker, Julia, H.S., and Amala R., 2004, In Vitro Cytotoxic Activity of Thai Medicinal Plant Used Traditionaly to Treat Cancer, J.Ethnopharmacol., 33-38. Byrne, L.T., Colegate, S.M., Dorling, P.R., and Huxtable, C.R., 1987, Imbricatonol, a Naphthol Naphthoquinone Dimer Isolated from Stypandra imbricata and Dianella revolute, Australian.J.Chem., 40(7), 1315-1320. Barrett, B., Kiefer, D., and Rabago, D., 1999, Assessing The Risks and Benefits of Herbal Medicine: An overview of Scientific Evidence, Altern.Ther.Health. Med., 5, 40-49. Colegate, S.M., Dorling, P.R., and Huxtable, C.R., 1986, Dianellidin, Stypandrol and Dianellinone: An Oxidation-Related Series from Dianella revolute, Phytochem., 25(5), 1245-1247. Cheeke, P.R., 1989, Toxicants of Plants Origin. Ed. CRC Press, Inc.USA. pp84-94. Chung, K.S., Takeatsu, K., Paul, P.H.B., and Ji-Xiang G., 1998, International Collation of Traditional and Folk Medicine:Northeast Asia Part III. Ed. World Scientific Publish. Co.Pte.Ltd. p159. Chee, Y.C, Kit-Lam, C., Koichi, T., and Hideji, I., 2001, Cytotoxic Activity of Typhonium flagelliforme (Araceae), Phytother. Res., 15, 260-262. Doyle, A., and Griffths, J.B. 2000. Cell and Tissue Culture for Medical Research. John Willey and Sons, Ltd.New York. 443p Fitowin, J.G. 2006. Pemanfaatan Pra Kepey (Dianella sp Lam.) Sebagai Tanaman Obat Tradisional Oleh Masyarakat Kampung Tablasupa Distrik Depapre, Kabupaten Jayapura. Skripsi Prog. Studi Biologi-FKIP, Univ. Cenderawasih. (Tidak dipublikasikan). Gul, H.I., Gul, M., and Hannine, O., 2002, Cytotoxic Activities of Some mono and bis Mannich Bases Derived from Acetophenone in Brine Shrimp Bioassay, Arzneimittel-Forschung., 52, 840-843. Kirana, C., Record, I., Mclntosh, G., and Jones, G., 2003, Screening for Antitumor Activity of 11 Species of Indonesia Zingiberaceae Using Human MCF-7 and HT-29 Cancer cell, Pharm.Biol., 41, 271-276. Kintzios, S.E., and Barberaki, M.G., 2004, Plants That Fight Cancer. Eds. Washington, D.C.CRC Press. 296p. Lojanapiwatna, V., Kovit, C., Kanchana, S., and Pichaet., 1982, Chemical Constituents Dianella ensifolia. J.Sci.Soc.Thailand., 8, 95-102. Li, S., Han, Q., Qiao, C., Song, J., Cheng, L.C., and Xu, H., 2008, Chemical Markers for the Quality Control of Herbal Medicines: An Overview, Chinese Medicine., 3(7), 1-16. Maturbongs, R.A, Arobaya, A.Y.S, Haetubu, C.D., and Pugu, Y.R., 2000, Etnobotani Suku Tepin di Pulau Salawati Kabupaten Dati II Sorong, Irian Jaya, Beccariana (Botanical Research Bulletin)., 2, 38-74. Nakayama, Y., Inoue, Y., Minagawa, N., Onitsuka, K., Nagata, J., Shibao, K., Hirata, K., Sako, T., Nagata, N., and Yamaguchi, K., 2009, Chemopreventive Effect of 4-[3,5-Bis (trimethylsilyl) benzamido] Benzoic Acid (TAC101.) On MNU-Induce Colon Carcinogenesis in Rat Model, Anticancer.Res., 29, 2059-2065. Rajesh, M.P., and Sahil, K.P., 2011, Cytotoxic Activity of Methanolic Extract of Artocarpus heterophyllus against A549, Hela and MCF-7 Cell Lines, J.Appli.Pharmac.Sci., 01(07), 167-171. Shirintorn, P., Pinyupa, P., Nisit, P., Siriluk, R., and Onrudee, M., 2004, Brine Shrimp Lethality Activity of Thai Medicinal Plant in The Famili Meliaceae, J. Naresuan University., 12 (2), 13-18. Subramaniam, D., Giridharan, P., Murmu, N., Shankaranarayanan, N.P., May, R., Houchen, C.W., Ramanujam, R.P., Balakrishnan, A., Vishwakarma, R.A., and Anant, S., 2008, Activation of Apoptosis by 1-Hydroxy-5,7- Dimethoxy-2-Naphthalene Carboxaldehyde a Novel Compound from Aegle marmelos, Cancer.Res., 68, 8573. Sakarkar, D.M., and Deshmukh, V.N., 2011, Ethnopharmacological Review of Traditional Medicinal Plants for Anticancer Activity, Inter.J. Pharm.Tech. Res., 3(1), 298-308. Zullies, I., Agung, E.N., and Winda, W., 2006, Efek Ekstrak Etanol Daun Erythrina fusca Lour (Cangkring) Terhadap Penekanan Ekspresi Enzim Siklooksigenase-2 Pada Kultur Sel Raji, Majalah Farmasi Indonesia., 17(2), 85-90. Zullies, I., Agung, E.N., dan Widyah, A., 2007, Penekanan Ekspresi COX-2 Pada Kultur Sel Raji oleh Ekstrak Kloroform Daun Cangkring (Erythrina fusca Lour.), Majalah Obat Tradisional., 11(39), 19-23.en_US
dc.identifier.isbn978-602-18711-0-2
dc.identifier.urihttp://hdl.handle.net/11617/2298
dc.description.abstractCancer is one of deathly diseases in the world. Many people conversely attempt to employ traditional medicine for primary health care, especially from Plants. Dianella nemorosa Lam. has their own local name in Papua, pra kepey and belongs to the Liliaceae family. It is one of the anticancer plants that is empirical efficacious usage. The aim of the research was to find out cytotoxic activity of methanol extract of D. nemorosa leaves against selected human cell line namely hormone-dependent breast carcinoma cell line (MCF-7), human breast carcinoma cell line (T-47D), colon carcinoma cell line (WiDR) and human-ßlymphoma cell line (Raji Cell). Leaves powder were extracted using methanol. Cytotoxic assay of the methanol extract was done using MTT [3-(4,5-dimetilthiazol-2-il)-2,5- difeniltetrazolium bromida) assay method in vitro. The result indicated that methanol extract of D. nemorosa leaves possessed cytotoxic activity in all tested cancer cell line, with the IC50 values of 1,794 µg/ml, 1,732 µg/ml, 1,719 µg/ml, and 1,049 µg/ml for MCF-7, T47D, WiDR and Raji cell line, respectively after incubation 24h. This species could be considered as potential sources of anticancer compounds. Further studies are necessary for chemical characterization of the active principles and more extensive biological evaluations.en_US
dc.publisherMuhammadiyah University Pressen_US
dc.subjectDianella nemorasa Lamen_US
dc.subjectcytotoxicen_US
dc.subjecthuman cell lineen_US
dc.subjectMTT assayen_US
dc.titleCytotoxic Activity of Tegari (Dianella nemorosa Lam; Liliaceae) Leaves Methanol Extract from Papua Against Human Cells Lines In Vitroen_US
dc.typeArticleen_US


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