The Potential of Jamur Dewa (Agaricusblazei Murril) Extract to Decrease Blood Glucose Diabetic Mice (Mus musculus)

Abstract

Diabetes mellitus (DM) or diabetes disease is caused by abnormal function of the pancreas to produce insulin, so blood glucose level is higher than normal blood glucose level. DM is a disease caused by a complication of other diseases, such as heart disease, hypertension. Type DM I diabetes occurs because the immune system is impaired. Therapy for the immune system is the key to cure diabetes. Therefore, the DM should be addressed as early as possible. The use of jamur dewa extract is considered effective as an alternative treatment of DM. Active substances in jamur dewa are linoleic acid, protein glucan, and D glucan polysaccharides. This content will boost the immune system. Protein content in jamur dewa play a role in pancreatic beta cells to regenerate increase insulin production. Examination of jamur dewa extract in this study was done using mice induced by streptozotocin. The results showed that jamur dewa extract can lower blood glucose levels in streptozotocin-induced mice at a minimum dose of 400 mg. Betaglucan binds to specific receptors present in macrophage cells. Macrophage cells are master cells in the immune system. Jamur dewa extract may boost immunity in people with DM type 1 and 2, hence, can improve the body's cells and insulin synthesis.