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dc.contributor.authorAriantari, Ni Putu
dc.contributor.authorVanadis, Putu Aurora
dc.contributor.authorWidyadana, Ketut Gegel Yoga
dc.contributor.authorTumewu, Lidya
dc.contributor.authorWidyawaruyanti, Aty
dc.date.accessioned2012-12-22T03:13:21Z
dc.date.available2012-12-22T03:13:21Z
dc.date.issued2012-06
dc.identifier.citationBharani, S.E.R., Asad, M., Dhamanigi, S.S., and Chandrakala, G.K., 2010, Immunomodulatory activity of methanolic extract of Morus alba Linn. (Mulberry) leaves, Pak. J. Pharm.Sci., 23(1), 63-68 Bloland, P.B., 2001, Drug Resistence in Malaria. WHO Switzerland Boonphong, S., Baramee, A., Kittakoop, P., and Puangsombat, P., 2007, Antitubercular and Antiplasmodial Prenylated Flavones from The Root of Artocarpus altilis, Chiang Mai J. Sci, 34(3), 339-343 Budimulya, A.S., Syafruddin, Tapchaisri, P., Wilariat, P., and Marzuki, S., 1997, The sensitivity of Plasmodium protein synthesis to prokaryotic ribosomal inhibitors, J Mol Biochem Parasitol., October, 137-141 Departemen Kesehatan RI, 1989, Materia Medika Indonesia V, Jakarta: Departemen Kesehatan Republik Indonesia, 549-553 Departemen Kesehatan RI, 2000, Inventaris Tanaman Obat, Edisi III, Jakarta: Departemen Kesehatan Republik Indonesia Evans, W.C. and Evans, D., 2002, Pharmacognosy, Fifteenth Edition, Philadelphia: Saunders, 223-337 Gandahusada, S., Ilahude, H.D., and Pribadi, W., 2004, Parasitologi Kedokteran, Edisi Ketiga, Jakarta: Balai Penerbit FKUI, 171-177 Hakim, E.H., 2007, Keanekaragaman Hayati Sebagai Sumber Keanekaragaman Molekul yang Unik dan Potensial untuk Bioindustri, Majelis Guru besar Institut Teknologi Bandung, 34 -35 Hakim, E.H., E. Junaidi, B.F.D.R Sofia and Y.A.S Anwar, 2010, Aktivitas Antimalaria dan Analisis Metabolit Sekunder Kayu Batang dan Kulit akar Artocarpus camansi Blanco (Moraceae), Indonesian Journal of Pharmaceutical Sciences, 8(2), 131-135 Hussein, M.S., El-Tawil, O.S., Yassin, N.E., and Abdou, K.A., 2010, The Protective Effect Of Morus Alba And Calendula Officinalis Plant Extracts On Carbon Tetrachloride-Induced Hepatotoxicity In Isolated Rat Hepatocytes, Journal of American Science, 6(10), 762-771 Jones, W. P. and Kinghorn A. D., 2006, Extraction of Plant Secondary Metabolites. In: Sarker, S. D., Latif, Z. and Gray, A. I. 2006, Natural Products Isolation, Second Edition. New Jersey: Humana Press Kohler, I., Siems, J., Siems, K., and Hernandes, M.A., 2002, In vitro Antiplasmodial Investigation of Medicinal Plants from El Savador, J. Bioscience., 57, 277-278 Nade, V.S., Kawale, L.A., Naik, R.A., and Yadav, A.V., 2009, Adaptogenic effect of Morus alba on chronic footshock- induced stress in rats, Indian J. Pharmacol., 41(6), 246-251 Nikkhah, E., Khayami, M., and Heidari, R., 2009, In vitro antioxidant activity of berry (Morus alba var nigra), International Journal of Plant Production, 3(4), 1735-8043 Saxena, S., Pant, N., Jain, D.C., and Bhakuni, R.S., 2003, Antimalarial Agent From Plant Sources, Current Science, 85(9), 1314-1326 Schlichthele, M., Wahlgren, M., Perlmann, H., and Scherf, A., 2000, Methods in Malaria Research, Third Edition, Manassas: Malaria Research and Reference Reagent Resource Center- American Type Culture Collection, 8- 10 Widyawaruyanti, A., Subehan, Kalauni, S.K., Awale, S., Nindatu, M., Zaini, N.C., Syafruddin, D., Asih, P.B.S., Tezuka, Y., and Kadota, S., 2007, New Prenylated Flavones from Artocarpus champeden SPRENG. and Their Antimalarial Activity In Vitro, J. Nat. Med., 61, 410-413en_US
dc.identifier.isbn978-602-18711-0-2
dc.identifier.urihttp://hdl.handle.net/11617/2427
dc.description.abstractMalaria is one of major global health problem, especially in sub-tropical and tropical countries. The increasing incidence of parasite resistance to recent antimalarial drug encourage any efforts in antimalarial drug discovery. Plants and traditional medicines are an important resource for the discovery and development of new antimalarial agents. Morus alba L. (Moraceae), commonly known as ”murbei”, has been traditionally used to treat fever and malaria. The aim of this research was to investigate antimalarial activity of methanolic extract of M. alba L. leaves against Plasmodium falciparum 3D7 in vitro. Dried leaves of M. alba L. was extracted with methanol yielded methanolic extract, followed by in vitro antimalarial activity assay. The result was analyzed by Probit Analysis. Phytochemical screening showed the presence of triterpenoids, flavonoids and glycosides. Result of this study revealed that methanolic extract of M. alba L. leaves was active against P. falciparum 3D7 in vitro, with an IC50 value of 0.02 µg/mL.en_US
dc.language.isoenen_US
dc.publisherMuhammadiyah University Pressen_US
dc.subjectMorus alba L.en_US
dc.subjectmethanolic extracten_US
dc.subjectPlasmodium falciparum 3D7en_US
dc.subjectantimalarialen_US
dc.titleIn Vitro Antimalarial Activity of Methanolic Extract of Morus Alba L. Leaves against Plasmodium Falciparum 3D7en_US
dc.typeArticleen_US


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