The Combined Effect of An Extracts of Morinda citrifolia L. Fruits and Carica papaya L. Leaves of Serum Transaminase and Bilirubin in Antituberculosis–induced Rats

Abstract

The activity testing from ethanolic exracts of Morinda citrifolia L fruits and Carica papaya L. leaves as a drug that prevents the liver damage (hepatoprotector) in antituberculosis- induced rats had been performed. The fourteen rats were devide into eigth groups. The normal control without a treatment, negatif control were given INH 10mg/200g BW and rifampicin 10mg/200g (bw), positif control were given INH-Rifampicin and methicol®, and the treatment group were given INH-Rifampicin with papaya and morinda extracts with with some variation of doses. Each group were given every day for 28 days. The measuring to monitor bilirubin serum, Alanine transaminase (ALT ) and aspartate transaminase (AST) levels on 0th, 14th, 21th and 28th day. The treatment group that given combination extract of C. papaya 120mg/200g and M. citrifolia fruit 20mg/200g BW showed serum Alanine transaminase (ALT ), Aspartate transaminase (AST) and serum bilirubin level were diminished significantly.