EFEK HEPATOPROTEKTIF EKSTRAK JAMUR LINGZHI (Ganoderma lucidum) PADA TIKUS TERINDUKSI PARASETAMOL

Abstract

Liver disease can be caused by virus, bacterium, parasite, drugs, alcohol, worm, or bad nutrition. One of drug which causing disease at liver is paracetamol where excessive usage or over dose will cause liver necrosis. Lingzhi (Ganoderma lucidum) contain ganodermic acid to restore liver function. Purpose of this research is to know hepatoprotective effect of ethanol extract lingzhi on the male rats that inducted by paracetamol. The research was conducted in five groups of male rats (each group contain five rats). The first group (normal control), the second group (control of toxic paracetamol 2,5 g/kg bw), the third until fifth group, were given Ganoderma lucidum extract with doses 0,5; 1 and 2 g/kg bw respectively. 24 hours after treatment, they were administrated by toxic dose paracetamol 2,5 g/kg bb. After 48 hours, SGPT activity were measured by GPT ALAT method and then their liver cells were examined by histology preparation. The results showed that the administered single dose of extract Ganoderma lucidum doses 0,5 : 1, and 2 g/kg bw for 7 seven days have a significant hepatoprotective effect in male rats 81,91%; 85,50% and 96,82% respectively. The examination of the liver cells by histology preparation shown that the administration of alcohol extract of Ganoderma lucidum doses 0,5; 1, and 2 g/kg bw have significant hepatoprotective effect againts toxicity of parasetamol (can reduce necrosis in liver).