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| dc.description.abstract | Natural disaster take place continually in Indonesia one of the chronically
impacts of these disasters is the existing of traumatic sense, in turn, it makes
individuals to be depressive. Many studies investigate the relationship among
depression, stress, and immune system, called psychoneuroimmunology. The result
of the study suggests that stress decrease the ability of immune system, therefore, it
can not unction well. Beside that, the people with depression also develop
disturbances in their mental status. The long-term objective of this research is
decrease the mental disturbance in Indonesia, and specifically it aims to find the
model and form of psychopharma, which is used to give therapy for the patients with
depression to achieve the recovering of mental status and increasing immune
response.
The patients with depression need mental therapy to patient their mental
from the serious mental disturbance in the future. The patients with depression may
run ascorbic acid in the body and may result in the inability to manage the problem
and then it can emerge the more serious depression. Ascorbic acid can be used to
improve the body immune; this substance exists in the meals in limited number, there
fore the body needs must be added by supplementary meals.
The problem of the research is, now is the most effective model to treat
patients with depression? And the objective of the research is to determine and to
find the combination of psychopharma and the model of the effective treatment for
the patients with depression in a disaster area. To achieve the objective, it is used
Randomized control Trial Double Blinded method, through the ways, year 1,
comparing the therapy single dose depression, that is fluoxetine 20 mg, fluoxetine 20
mg combined by ascorbic acid 100 mg and controlled group, consist of normal
control and treated control, pre-examining on the mouse of 300 g in weight. Finally,
all of groups are assessed their CD4 immune. Year II, the result of first year
research, it is given to the depressed patient and compare the coping mechanism,
CD 4 immune response, and patients’ response toward the new model of drug. After
this research has been conducted, it is expected that the finding will be useful as the
new knowledge of the therapeutic model and the drug form to the depressed patient.
The result of the data analysis exhibits the mean of CD4 score of the group,
who give fluoxetine combined by ascorbic acid is highest than the other group, that
is 34.82. Therefore, it can be concluded that there is different among the groups
given combined therapy, depressed and control therapy, with 99.336 of F and 0.000
of values.
The conclusion of this research is that the combined therapy is a therapy,
resulting best immune response CD4 on an acute depression state than the other therapy. The finding of this research is a model and new drug form for depressed
patient, which will be examine on the second year. | en_US |
