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dc.contributor.authorDjumadi
dc.contributor.authorSantoso, Broto
dc.date.accessioned2013-02-06T03:47:06Z
dc.date.available2013-02-06T03:47:06Z
dc.date.issued2008-09
dc.identifier.citationAnonim, (2001), Info Malaria, Http://indosiar.com-News.htm. Anonim, (2003), Malaria dan Penaganannya, http://indosiar.com-News.htm. Atamimi F., (2001), Tiga senyawa baru Cassanefurano diterpen hasil isolasi dari daging biji Bogore (Caesalpinia erista l.), asal Sulawesi Selatan sebagai bahan dasar obat antimalaria, Sci & Tech, Vol. 2 No 1, pp 12-24. Babu, T.D., Kuttan, G., Padikkala, J., (1995), Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban, Journal of Ethnopharmacology, Vol. 48, pp. 53-57. Bray, D. H., Warhurst, D. C., Connolly, J. D., O’Neill, M. J. and Phillipson, J. D., (1990), Plants as source of antimalarial drug. Pt.7 activity of some species of Meliaceae plants and their constituent limoids, Phytother. Res., Vol. 4, pp. 29– 35. Bruce-Chwatt, L.J., (1980), Essential Malariology, Willian Heineman Medicals Books Ltd, London, pp. 31-32, 164-169. Bunpo, P., Kataoka, K., Arimochi, H., Nakayama, H., Kuwahara, T., Bando, Y., Izumi, K., Vinitketkumnuen, U., Ohnishi, Y., (2004), Inhibitoryy effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in intestines of F344 rats, Food and Chemical Toxicology, Vol. 42, pp. 1987-1997. Chanphen, R., Thebtaranonth, Y., Wanauppathamkul, S. and Yuthavong, Y., (1998), Antimalarial Principles from Artemisia indica, J. Nat. Prod., Vol. 61, pp. 1146– 1147. Cheng, C.L., Guo, J.S., Luk, J., Koo, M.W.L., (2004), The healing effects of Centella extract and asiatiocoside on acetic acid induced gastric ulcers in rats, Life Sciences, Vol. 74, pp. 2237-2249. Cheng, C.L., Koo, M.W.L., (2000), Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats, Life Sciences, Vol. 67, pp. 2647-2653. Dewi, R.M., dan Sulaksono, E., (1994), Pengaruh pasase plasmodium berghei pada mencit galur Swiss, Cermin Dunia Kedokteran, no.. 94, Jakarta, pp. 61-63, Francois, G., Passreiter, C.M., Woerdenbag, H.J. and Looveren, M.V., (1996), Antimalarial Activities and Cytotoxic Effects of Aqueous Extracts and Sesquiterpene Lactones from Neurolaena lobata, Planta Med., Vol. 62, pp. 126–129. Gandahusada, S., Ilahude, H,D., Pribadi, W., (1998), Parasitologi Kedokteran, Edisi 3, Fakultas Kedokteran Universitas Indonesia, Jakarta. Gnanapragasam, A., Ebenezar, K.K., Sathish, V., Govindaraju, P., Devaki., (2004), Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats, Life Sciences, Vol. 76, pp. 585-597. Gupta, Y.K., Kumar, M.H.V., Srivastava, (2003), Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats, Pharmacology Biochemistry and Behavior, Vol. 74, pp. 579-585. Hamid, A.A., shah, Z.M., Muse, R., Mohamed, S., (2002), Chacterisation of antioxidative activities of various extracts of Centella asiatica (L.) Urban, Food Chemistry, Vol. 77, pp. 465-469. Hussin, M., Hamid, A.A., Mohamad, S., Saari, N., Ismail, M., Bejo, M.H., (2005), Protective effect of Centella asiatica extract and powder on oxidative stress in rats, Food Chemistry, article in press. Jain, R., (2002), Recent Advancements in Antimalarial Drug Development: Review Article, CRIPS, vol 3, No 4. Jawtz E., Joseph L.M., Edward A.A., Geo F.B., janet S.B., L. Nicholaus Ornaston, (1995), Mikrobiologi Kedokteran. Edisi 20, Ptj. Edi Nugroho, Maulany, Penerbit Buku kedokteran EGC, Jakarta; pp. 153-158 Jayashree, G., Muraleedhara, G.K., Srdarslal,S., Jacob, V.B, (2003), Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice, Fitoterapia, Vol. 74, pp. 431-434. Jayathirtha, M.G., Mishra, S.H., (2004), Preliminaary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica, Phytomedicine, Vol. 11, pp. 361-365. Kirby, G. C., Paine, A., Warhurst, D. C., Noamese, B. K. and Phillipson, J. D., (1995), In vitro and In vivo antimalarial activity of Cryptolepine, a plant-derived indoloquinoline, Phytother. Res., Vol. 9, pp. 359–363. Kitagawa, I., Mahmud, T., Simanjuntak, P., Hori, K., Uji, T. and Shibuya, H., (1993), Dehatrine, an antimalarial bisbenzylisoquinoline alkaloid from the Indonesian medicinal plant Belischmiedia madang, isolated as a mixture of two rotational isomers, Chem. Pharm. Bull., Vol. 41, pp. 997–999. Klayman, D. L., 1985, Quinghaosu (artemisinin): An Antimalarial Drug from China. Science, Vol. 228, pp. 1049–1055. Kumar, M.H.V., Gupta, Y.K., (2002), Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats, Journal of Ethnopharmacology, Vol. 79, pp. 253-260. Likhitwitayawuid, K., Angerhofer, C. K., Cordell, G. A. and Pezzuto, J. M., (1993), Cytotoxic and Antimalarial Bisbenzylisoquinoline Alkaloids from Stephania erects. J. Nat. Prod., Vol. 56, pp. 30–38. Likhitwitayawuid, K., Chanmahasathien, W., Ruangrungsi, N. and Krungkrai, J., (1998), Xanthones with Antimalarial Activity from Garcinia dulcis. Planta Med., Vol. 64, pp. 281–282. Moretti, C., Deharo, E., Sauvain, M., Jardel, C., David, P. T. and Gasquet, M., (1994), Antimalarial activity of Cedronin, J. Ethnopharmacol., Vol. 43, pp. 57–61. Mursito, B., (2002), Ramuan Tradisional untuk Penyakit Malaria, Cetakan Pertama, Penebar Swadaya, Jakarta. Padmaja, R., Arun, P.C., Prashanth, D., Deepak, M., Amit, A., Anjana, M., (2002), Brine shrimp lethality bioassay of selected Indian medicinal plants, Fitoterapia, Vol. 73, pp. 508-510. Park, B.C., Bosire, K.O., Lee, E.S., Lee, Y.S., Kim, J.A., (2005), Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells, Cancer Letter, Vol. 218, pp. 81-90. Prabowo, A., (2004), Malaria, Mencegah dan Mengatasinya, Cetakan Pertama, Puspa Swara, Jakarta. Sampson, J.H., Raman, A., Karlsen, G., Navsaria, H., Leigh, I.M., (2001), In vitro keratinocyte antiproliferant effect on Centella asiatica extract and triterpenoid saponins, Phytomedicine, Vol. 8 (3), pp. 230-235. Saxena S., Neerja Pant, D.C. Jain and R.S. Bhakuni, (2003), Antimalarial agents from natural sources, Current Science, Vol. 85, No 9, pp; 1314-1329. Schuster, F.L., 2002, Cultivation of Plamodium spp., Clinical Microbiology Reviews, Vol. 15, No. 3, pp 355-364. Sevrina, E.D., (2006), Uji aktivitas antimalaria ekstrak n-heksana, kloroform, etilasetat, dan etanol dari daun Pegagan (Centella asiatica Urb.), terhadap plasmodium berghei secara in vivo dan profil kromatografi lapis tipisnya, Skripsi, Fakultas Farmasi, Universitas Muhammadiyah Surakarta. Sharman, S.C. and Agarwal, V.K., 1993, Brucea javanica (Linn.) Merr.: A Potent Anticancer and Antimalarial Plant–a review, Indian J. Pharm. Sci., Vol. 55, pp. 77–85. Shulman S.T., John P.D., and Herbert M.S., (1992), Dasar Biologi dan Klinis Penyakit Infeksi, Penterjemah, Soeprapto S., Gadjah Mada University Press, Yogyakarta, Indonesia. Soedarto, (1990), Protozologi Kedokteran, Cetakan pertama, Widya Medika, Jakarta. Solet, J.M., Francoise, B.M., Galons, H., Sp[agnoli, R., Guignard, J.L., Cosson, L., (1993), Glucosylation of thiocolchicine by a cell suspension culture of Centella asiatica, Phytochemistry, Vol. 33 (4), pp. 817-820 Souri, E., Nateghpour, M., Farsam, H., Kaji, Z., Hamedi, Y., Amanlou, M., 2002, In Vitro Activity of Mefloquine and Its Enantiomers against Plasmodium falciparum, Iranian Journal of Pharmacology & Therapeutics, Vol. 1, No. 1, pp 17-19. Subathra, M., Shila, S., Devi, M.A., Panneerselvam, C., (2005), Emerging role of Centella asiatica in improving age-related neurological antioxidant status, Experimental Gerontology, Vol. 40, pp. 707-715. Sutisna, P., (2004), Malaria Secara Ringkas, Cetakan Pertama, Penerbit Buku Kedokteran EGC Jakarta. Syamsuhidayat, S.R., Hutapea, J.R., (1991), Inventaris Tanaman Obat Indonesia, Jilid pertama, Badan Penelitian dan Pengembangan, Departemen Kesehatan Republik Indonesia, Jakarta. Thebtaranonth, C., Thebtaranonth, Y., Wanauppathamkul, S. and Yuthavong, Y., (1995), Antimalarial Sesquiterpenes from Tubers of Cyperus rotundus: Structure of 10,12-peroxycalamenene, a Sesquiterpene Endoperoxide. Phytochemistry, Vol. 40, pp. 125–128. Trager, W. and Jesen, J.B., (1976), Human Malaria Parasites in Continous Culture Science, dalam Methods in Malaria Research, Third Ed, Edited by Martha Sclichtherle, Mats W., Hedving P., Arthur Scherf, Manassas, Virginia. Wang, X., Zheng, Y., Zuo, J., Fang, J., (2005), Structural fetures of an immunoactive acidic arabinogalactan from Centella asiatica, Carbohydrate Polymers, Vol. 59, pp. 281-288. Wang, X.S., Dong, Q., Zuo, J.P., Fang, J.N., (2003), Structure and potential immunological activity of a pectin from Centella asiatica (L.) Urban, Carbohydrate Research, Vol. 338, pp. 2393-2402. Wijayanti, M.A., 2007, Malaria, Materi Kuliah Kultur Plasmodium, Bagian Parasitologi Fakultas Kedokteran UGM, Yogyakarta. Wijeweera, P., Arnason, J.T., Koszycki, D., Merali, Z., (2006), Evaluation of anxiolytic properties of Gotukola – (Centella asiatica) extracts and asiaticoside in rat behavioral models, Phytomedicine, article in press. Yen, G.C., Vhen, H.Y., Peng, H.H., (2001), Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of emerging edible plants, Food and Chemical Toxicology, Vol. 39, pp. 1045-1053. Zainol, M.K., Hamid, A., Yusof, S., Muse, R., (2003), Antioxidative activity and total phenolic compounds of leaf, root and peotile of four accesions of Centella asiatica (L.) Urban, Food Chemistry, Vol. 81, pp. 575-581.en_US
dc.identifier.urihttp://hdl.handle.net/11617/2653
dc.description.abstractTelah dilakukan penelitian untuk mengamati aktivitas antiplasmodium dari ekstrak metanol kulit kayu mimba (Azadirachta indica). Fraksi yang diamati adalah fraksi nonpolar, semipolar dan polar yang diperoleh dengan metode kromatografi cair vakum dengan eluen n-heksana-etilasetat. Hasil penelitian menunjukkan bahwa fraksi nonpolar memiliki aktivitas antiplasmodium yang paling tinggi terhadap P. falciparum strain D10 secara in vitro, dengan nilai IC50 6,23 µg/mL, sedangkan fraksi semipolar dan polar memiliki aktivitas antiplasmodium yang makin menurun, dengan nilai IC50 masing-masing 11,02 dan 11,37 µg/mL. Hasil analisis KLT dan uji fitokimia menunjukkan bahwa fraksi nonpolar dan semipolar memiliki kandungan senyawa kelompok triterpenoid, alkaloid dan flavonoid, sedangkan fraksi polar hanya teridentifikasi adanya senyawa flavonoid. Aktivitas antiplasmodium sangat dipengaruhi oleh keberadaan senyawa-senyawa nonpolar (triterpenoid).en_US
dc.description.sponsorshipBERSAING DIKTIen_US
dc.publisherLPPM UMSen_US
dc.subjectAzadirachta indicaen_US
dc.subjectaktivitas antiplasmodiumen_US
dc.subjectP. falciparum strain D10en_US
dc.titlePEMISAHAN SENYAWA-SENYAWA YANG BERSIFAT ANTIMALARIA DARI EKSTRAK METANOL KULIT KAYU MIMBA ( Azadirachta Indica JUSS)en_US
dc.typeThesisen_US


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