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dc.contributor.authorSujono, Tanti Azizah
dc.contributor.authorWahyuni, Arifah Sri
dc.contributor.authorDa’i, Muhammad
dc.contributor.authorTrisharyanti, Ika
dc.contributor.authorKusumowati, Diah
dc.date.accessioned2015-02-03T06:51:11Z
dc.date.available2015-02-03T06:51:11Z
dc.date.issued2015-01-24
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dc.identifier.issn2407-9189
dc.identifier.urihttp://hdl.handle.net/11617/5164
dc.description.abstractPreliminary research showed that meniran herbs (Phyllanthus niruri L.) had various biological activities such as anticarcinogen, hepatoprotective, antioxidant. A medicinal plant to be developed into a standardized herbal medicine, it is needed safety test in animal (preclinic test). This study aimed to evaluate the influence of ethanolic extract of meniran on liver function in rats given for the long term. A total of 36 male and female rats were divided into 3 groups: control (aquadest), ethanolic extract of meniran with dose 50 mg/kgbw and 250 mg/kgbw, each group consisted of 6 rats. Treatment was given with repeated doses for 90 days. To evaluate the liver function, there were 2 parameters: quantitative and qualitative data. The quantitative data include SGPT (serum glutamate piruvate transaminase) and SGOT (serum glutamate oxaloacetate transaminase) and qualitative data was histopathology of liver. SGPT and SGOT level were measured on days 0, and 90. SGPT and SGOT level were compared between before and after treatment using paired t test with a 95% confidence level. Data of histopathology compared to the control group. The results showed that the ethanolic extract of meniran dose 50 and 250 mg/kg body weight administered repeatedly for 90 days had no toxic effect on liver function of male and female rats.en_US
dc.publisherUniversitas Muhammadiyah Surakartaen_US
dc.subjectPhyllanthus niruri Len_US
dc.subject90 daysen_US
dc.subjectSGPTen_US
dc.subjectSGOTen_US
dc.subjecthistopathologyen_US
dc.titlePengaruh Pemberian Ekstrak Etanol Meniran (Phyllanthus Niruri L) Selama 90 Hari terhadap Fungsi Hati Tikusen_US
dc.typeArticleen_US


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