Pengaruh Kitosan Olahan Kulit Udang Putih terhadap Penurunan Kadar Trigliserida Plasma Tikus Putih (Rattus norvegicus)

Abstract

Chitosan is a natural compound (aminopolysaccharide) earned through a process deacetylation base on chitin derived from processed shrimp white skin, are non-toxic, biodegradable, and have power fastening fat is higher than other fibers, so capable of preventing absorption body fat. This study aims to determine the effect chitosan to the triglyceride plasma level of white mouse. This study is laboratory experimental. The sample consists of a negative control group, positive control group (Simvastatin), chitosan dose of 3500 mg, 4500 mg, and 5500 mg group. The results showed that positive control group with all the variations dose chitosan is not different (ñ>0.05), whereas the negative control treatment with all groups is different (ñ<0.05). The conclusion, chitosan is able to decrease the triglyceride plasma level of white mouse (Rattus norvegicus) in second week. The effective dose is the 3500 mg.