| dc.identifier.citation | [1]. Widjajakusuma, EC, Hendriati, L, Ferawati, dan Surjadhana, A: Toxicity Test and Pharmacology of Andrographis paniculata and anticancer of Centella asiatica, Research Report of Traditional Medicine Research Centre, Widya Mandala Surabaya Catholic University, 2009. [2]. M. Young, The Technical Writer’s Handbook. Mill Valley, CA: University Science, 1989. [3]. Hadisoewignyo, L, Ervina M , dan Soegianto, L: Antioxidants Activity, Anti-inflammatory, and Ulcerogenic Test of Combination of Sambiloto Extract and Salam Leaf Extract as regards the Antidiabetic, Research Report, Widya Mandala Surabaya Catholic University, 2012. [4]. Ministry of Health Republic of Indonesia: Standar Umum Ekstrak Tumbuhan Obat. Jakarta; 2000. [5]. Foundation for the Development of Natural Products Drug Phyto Medica: Penapisan Farmakologi, Pengujian Fitokimia dan Pengujian Klinik. Jakarta; 1993 [6]. Ministry of Health Republic of Indonesia: Materia Medika Indonesia. Jakarta; 1980. | in_ID |
| dc.description.abstract | Sambiloto herbs (Andrographis paniculata Nees) and salam leaves (Syzygium polyanthum), which are effective to reduce blood sugar level with different mechanism, have been suggested to produce a synergy as antioxidant and anti-inflammatory agent, hence the optimum combination formula is remained to be elaborated. By reducing blood sugar level and showing antioxidant, and anti-inflammatory activity, both plants were hypothesized of its ability ameliorating diabetes mellitus complexicity. This study aimed to discover the optimal combination formula sambiloto herbs (Andrographis paniculata Nees) and salam leaves (Syzygium polyanthum) water fraction to produce anti-inflammation effect. Carrageenan was used to induced the inflammatory condition. Optimization was conducted by factorial design utilising 2 factors and 2 levels. Both factors, sambiloto herbs (Andrographis paniculata Nees) and salam leaves (Syzygium polyanthum) in the range of low level 1:10 and high level 10:1 with the used doses were 100 mg/kg BW at low level and 300 mg/kg BW for high level. The observed parameters were anti inflammation potential percent and edema rate. Conclusively, this study proposed that optimum combination formula of sambiloto herbal : salam leaves water fraction = 1.14 : 9.87 with 234 mg dose. The combination formula was theoretically resulted the optimum anti inflammation potential percent of 45.68%, and ER of 38.39% compared with other combination formulas. | in_ID |
