Antidiabetic Activity of Durian (Durio zibethinus Murr.) and Rambutan (Nephelium lappaceum L.) Fruit Peels in Alloxan Diabetic Rats

Abstract

Durian (Durio zibethinus Murr.) and rambutan (Nephelium lappaceum L.) fruit peels had been reported contain flavonoids that allegedly had antidiabetic activity. This study aims to determine the antidiabetic activity of the ethanolic extract of durian and rambutan fruit peels in alloxan diabetic rats. The research method is pre and post control group design. Forty white male rats of Wistar strain were divided into 8 treatment groups. Group I (negative control) were given solution of CMC-Na 0,5%, group II (positive control) were given Glibenclamide 0.45 mg/kgb.w., group III, IV, and V were treated with ethanol extract of durian fruit peel with consecutive doses 125, 250, and 500 mg/kgb.w. Groups VI, VII, and VIII were treated with ethanol extract of rambutan fruit peel with successive doses 125, 250, and 500 mg/kgb.w. Previously the rats induced alloxan intraperitoneally with dose 150 mg/kgb.w. On the 4th day the rats with blood glucose levels ± 200 mg/dL is used for research, and considered as diabetic rats. Treatment of animal testing for 11 days with 3 times taking blood in day 0, 4, and 11. The results showed the ethanolic extract of the durian and rambutan fruit peels with each doses 125, 250, and 500 mg/kgb.w. have antidiabetic activity in alloxan diabetic rats. The percentage reduction in blood glucose levels of ethanol extract of durian and rambutan fruit peels with each doses 125, 250, and 500 mg/kgb.w. are 16.55±2.99%, 35.09±3.84%, 50.19±3.66%, 22.65±2.10%, 49.05±3.22%, 61.76±4.26%, respectively.