Pengaruh Pemberian Ekstrak Herba Meniran (Phyllanthus Niruri ) Terhadap Volume Urin Mencit Hiperurisemia

Abstract

Meniran (Phyllanthus niruri L) herbal extract had shown antihyperuricemia effect through uricosuric action. The purpose of this study was to determine the effect of 200 mg/kg.bw extracts in increase the urine volume of hyperuricemic mice. This study was a quasi-experimental with a complete randomized block design. Fifteen mice were divided into 3 groups. Such as, normal group was given aqua pro injection 1 mL/20 g.bw (i.p) and distilled water with 0.5 mL/20g.bw (po), negative group was given 250 mg/kg potassium oxonate (i.p) and distilled water with 5 mL/20g.bw (p.o), treatment group was given 250 mg/kg.bw potassium oxonate (i.p) and 200 mg/ kg.bw extracts of meniran (p.o). Cumulative urine volume was measured at the 0,1,2,3,4,5,6,7,8 and 24 hour for 3 days. Volume of drinking and feed were accounted for 3 days. Data was analyzed with Kruskal-Wallis and Mann Whitney Test. The result showed that in negative group the urine volume produced was higher than the normal group (p = 0.007). Meanwhile, urine volume of others group was lower than negative control (p = 0.011). Based on the data, meniran extract could not increase the urine volume in hyperuricemia mice, aside from the extract can increase the urine volume in normal mice.