Sintesis Senyawa 4 Formil 2 Metoksifenil 3,4,5 Trihidroksibenzoat Melalui Pemanasan

Abstract

Gallic acid and vanillin are medicines that have anticancer potency of synergism, if both of them were reacted in order to get new compound and to have a better activity. Its docking study expressed a better value than native ligand of receptor. The resultis expected to have a positive correlation with biological activity. Synthesis of gallicderivatives had been donefrom gallic acid and vanillin by reacting sodium vanillate with gallic acid at 40°C. The product was tested by chromatographyanalyzes, melting point tester and its IR spectrum using FTIR. The white powder yieldobtained was 26.88%. Its chromatogram showed the formation of a new compound at Rf 0.5. The test results showed its IR spectrum of ester group at wavelength number of 1280 to 1188cm-1. It can be concluded that synthesis of gallic or 4-formyl-2- methoxyphenyl-3,4,5-trihidroxybenzoichad apparently success by heating at 40 derajat C.