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dc.contributor.authorSantoso, Bilal Subchan A.
dc.contributor.authorKhotib, Junaidi
dc.contributor.authorSukardiman
dc.date.accessioned2012-12-14T07:29:14Z
dc.date.available2012-12-14T07:29:14Z
dc.date.issued2012-06
dc.identifier.citationBalmer, C.M., Valley A.W. and Iannucci, A. 2006.Cancer Treatment and Chemotherapy.In: J.T. DiPiro, R.L. Talbert, G.C. Yee, G.R. Matzke, B.G. Wells, and L.M. Posey (Eds.). Pharmacotherapy: A Pathophysiologic Approach, Sixth Edition, New York: McGraw-Hill Companies, Inc. Banerjee, S., Ramos, C.B., Aggrawal, B.B., 2002. Suppression of 7, 12- Dimethylbenz(a)anthracene-induced Mammary Carcinogenesis in Rats by Resveratrol: Role of Nuclear Factor B, Cyclooxygenase 2 and Matrix Metalloprotease 9. Cancer Research. Cotran RS, Kumar V, Robbins SL.,2003. Robbins Pathologic Basis of Disease, pp. 1067 Philadelphia: WB Saunders Company. Liu, S., Edgerton SM., Moore DH.,et al. 2001. Measures of Cell Turnover (Proliferation and Apoptosis) and Their Association with Survival in Breast Cancer. Clin Cancer Res. Liu, YF.,Wei, PK. 2005. Effect on the volatile oil of Kaempferia galanga L. inhibiting the growth and metastasis of human gastric carcinoma. Journal of Nanjing Railway Medical College. Nicol, C.J., Yoon, M., Ward, J.M., Yamashita, M., Fukamachi, K., Peters, J.M. and Gonzales, F.J., 2004. PPAR Influences Susceptibility to DMBAInduced Mammary, Ovarian and Skin Carcinogenesis. Carcinogenesis. Siregar, GA. 2007. Deteksi dini dan penatalaksanaan kanker usus besar. in: Pidato Pengukuhan Jabatan Guru Besar Tetap dalam Bidang Ilmu Penyakit Dalam pada Fakultas Kedokteran, Sumatera Utara. Sugiyama, T., Osaka, M., Koami, K., Maeda, S., and Ueda, N., 7,12-DMBA Induced Rat Leukemia: A Review with Insights into Future Research. Leukimia Research. Sutadi, S.M., 2003. Pola Keganasan Saluran Cerna Bagian Atas dan Bawah Secara Endoskopi di H. Adam Malik-Medan, Medan: Fakultas Kedokteran Bagian Ilmu Penyakit Dalam Universitas Sumatera Utara. Xiao, Y., Wei, PK., Li, J., Shi, J., Yu, ZH.,Lin, HM. 2006. Effects of Rhizoma kaempferiae volatile oil on tumor growth and cell cycle of MKN- 45 human gastric cancer cells orthotopically transplanted in nude mice. Journal of Chinese Integrative Medicine. Ying, X., Hang, C. 2002. Study on the anti-carcinogenic effects of three compounds in Kaempferia galanga L. Journal of Hygiene Research.en_US
dc.identifier.isbn978-602-18711-0-2
dc.identifier.urihttp://hdl.handle.net/11617/2344
dc.description.abstractEthyl p-methoxycinnamate effectively inhibit the growth of cancer through a mechanism related to cell cycle regulation and apoptosis induction. We determined Kaempferia galanga that containing ethyl p-methoxycinnamate can increase the apoptosis activity in colon cancer cells. This study was designed to investigate effect of oil fraction from Kaempferia galanga alcoholic extract on apoptosis activity in mice colon cancer. Dimethylbenz(a)anthracene (DMBA)-induced colon cancer in mice is a useful model to investigate the changes of epithelial cells that occur during colon cancer progression. Colon cancer model was induced six times once a week by oral DMBA 50 mg/kg body weight. Administration of three different doses ethyl p-methoxycinnamate of oil fraction are 7.8 mg/kg, 23.4 mg/kg and 78 mg/kg which given to models during 30 days. Data analysis of immunohistochemical preparations was obtained and processed with one-way ANOVA statistical test, followed with post hoc test. Results showed that mice which given samples test increases apoptosis activity in colon cancer epithelial cells. The most effective dose of oil fraction increases apoptosis activity is containing ethyl p-methoxycinnamate 23.4 mg/kg body weight of mice.en_US
dc.language.isoenen_US
dc.publisherMuhammadiyah University Pressen_US
dc.subjectKaempferia galangaen_US
dc.subjectethyl p-methoxycinnamateen_US
dc.subjectdimethylbenz(a)anthra-ceneen_US
dc.subjectcolon canceren_US
dc.subjectapoptosisen_US
dc.titleOil Fraction from Kaempferia galanga Alcoholic Extract Increases Apoptosis Activity in Mice Colon Canceren_US
dc.typeArticleen_US


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