The Combined Effect of An Extracts of Morinda citrifolia L. Fruits and Carica papaya L. Leaves of Serum Transaminase and Bilirubin in Antituberculosis–induced Rats
H, Nurul Jannah
Wahyu Wardani, Wening
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The activity testing from ethanolic exracts of Morinda citrifolia L fruits and Carica papaya L. leaves as a drug that prevents the liver damage (hepatoprotector) in antituberculosis- induced rats had been performed. The fourteen rats were devide into eigth groups. The normal control without a treatment, negatif control were given INH 10mg/200g BW and rifampicin 10mg/200g (bw), positif control were given INH-Rifampicin and methicol®, and the treatment group were given INH-Rifampicin with papaya and morinda extracts with with some variation of doses. Each group were given every day for 28 days. The measuring to monitor bilirubin serum, Alanine transaminase (ALT ) and aspartate transaminase (AST) levels on 0th, 14th, 21th and 28th day. The treatment group that given combination extract of C. papaya 120mg/200g and M. citrifolia fruit 20mg/200g BW showed serum Alanine transaminase (ALT ), Aspartate transaminase (AST) and serum bilirubin level were diminished significantly.