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dc.contributor.authorSunarni, Titik
dc.contributor.authorPrastiwi, Rini
dc.contributor.authorMardiyono
dc.contributor.authorRinanto, Yudi
dc.contributor.authorH, Nurul Jannah
dc.contributor.authorWahyu Wardani, Wening
dc.date.accessioned2012-12-22T04:15:17Z
dc.date.available2012-12-22T04:15:17Z
dc.date.issued2012-06
dc.identifier.citationAdhvaryu M.R., Reddy N, Parabia M.H., 2007, Effects of four Indian medicinal Herbs on Isoniazid, Rifampicin and Pyrazinamide induced hepatic injury and immunosuppression in guinea pigs, Department of Biosciences Veer Narmad South Gujarat University, India, pp 13(23) pp. 3199- 3205. Arsyad Z., 1989, Evaluasi Faal Hati pada Penderita Tuberkulosis Paru yang Mendapat Terapi Obat Anti Tuberkulosis, Cermin Dunia Kedokteran, No. 110, p. 15-18. Anonymous, 2009, Buah mengkudu, diambil dari: http://www.Asiamaya .com/jamu/isi mengkudu_Morinda citrifolia,L.htm, diakses 29 Juni, 2009. Christina W., 2005 cit Solomon, 1998, Peluang Pengembangan Minuman Fungsional Dari Buah Mengkudu (Morinda Citrifolia L.), Jurnal Litbang Pertanian, 24(4), pp. 149-155. Depkes, 1989, Materia Medika Indo-nesia, Departemen Kesehatan Repu-blik Indonesia, Jakarta, Jilid V, pp . 119. Depkes, 2000, Inventaris Tanaman Obat Indonesia (1), Departemen Kesehatan dan Kesejahteraan Sosial Republik Indonesia, Jakarta, Jilid 1, pp. 51-52. Gun S., 2007, Farmakologi dan Terapi, Departemen Farmakologi dan Terapeutik Fakultas Kedokteran Universitas Indonesia, Jakarta, Penerbit Gaya Baru, p. 614. Hariana A., 2008, Tumbuhan Obat dan Khasiatnya, Penerbit Swadaya, Jakarta, pp. 118-124. Hembing W., 2008, Tumpas Hepatitis dengan Ramuan Herbal, Penerbit PT Elex Media Komputindo Gramedia, Jakarta. Irfianti T.R., 2007, Pengaruh Pemberian Mengkudu (Morinda citrifolia L.) Terhadap Hepatotoksisitas Karbon Tetraklorida pada Mencit [skripsi], Universitas Sebelas Maret, Surakarta. Katzung and Bertram G., 2004, Farmakologi Dasar dan Klinik, Bagian Farmakologi Fakultas Kedokteran, Jakarta, Universitas Indonesia, Terjemahan: Basic and Clinical Pharmacology, 8th ed.; p. 93. Marsono H., 2007, Pengaruh Praperlakuan Ekstrak Etanolik Buah Mengkudu (Morinda Citrifolia) Terhadap aktivitas Enzim GPT dan GOT Akibat Pemberian Paracetamol Pada Tikus Putih Jantan Galur Wistar, [Skripsi], Universitas Setia Budi, Surakarta, 2007. Pal R, Vaiphei K, Sikander A, Singh K, Rana SV., 2006, Effect of garlic on isoniazid and rifampisin-induced hepatic injury in rats, Departement of Gastroenterology, Postgraduate Institute of Medical Education and Research, India, p. 636-639. Rendi I., 2009, Pengaruh Ekstrak Etanol 70% Buah Mengkudu (Morinda citrifolia L.) Terhadap Aktivitas Enzim ALT dan AST Pada Tikus Putih Galur Wistar yang Diinduksi Isoniazid dan Rifampisin. [Skripsi], Universitas Setia Budi, Surakarta. Ridwan D.K., 2009, Pengaruh Ekstrak Etanol 70% Buah Mengkudu (Morinda citrifolia L.) Terhadap Kadar Bilirubin Serum Pada Tikus yang Diinduksi Isoniazid dan Rifampisin, [Skripsi], Universitas Setia Budi, Surakarta, 2009. Ronny, A.W., 2009, Efek Ekstrak Etanol 70% Buah Mengkudu (Morinda citrifolia L.) Terhadap Histologi Hati Tikus Putih yang Diinduksi Dengan Isoniazid dan Rifampisin, [Skripsi], Fakultas Farmasi, Universitas Setia Budi. Robinson T., 1995, Kandungan Organik Tumbuhan Tinggi, Penerbit ITB, Bandung, 1995. pp. 191-193. Sulaiman, 1990, Gastroenterology Hapatologi, Penerbit CV Agung Seto, Jakarta, p. 241-245. Wijayakusuma, 2002, Penyembuhan dengan Mengkudu Morinda citrifolia. Edisi III. Penerbit Milenia Popular. Jakarta. Zain A., 2006, Pengaruh Pemberian Perasan Buah Mengkudu (Morinda citrifolia L.) Terhadap Gambaran Histopatologi Ginjal Tikus Putih (Rattus norvegicus) Diet Lemak Tinggi, [Skripsi], Universitas Setia Budi, Surakarta, 2006.en_US
dc.identifier.isbn978-602-18711-0-2
dc.identifier.urihttp://hdl.handle.net/11617/2433
dc.description.abstractThe activity testing from ethanolic exracts of Morinda citrifolia L fruits and Carica papaya L. leaves as a drug that prevents the liver damage (hepatoprotector) in antituberculosis- induced rats had been performed. The fourteen rats were devide into eigth groups. The normal control without a treatment, negatif control were given INH 10mg/200g BW and rifampicin 10mg/200g (bw), positif control were given INH-Rifampicin and methicol®, and the treatment group were given INH-Rifampicin with papaya and morinda extracts with with some variation of doses. Each group were given every day for 28 days. The measuring to monitor bilirubin serum, Alanine transaminase (ALT ) and aspartate transaminase (AST) levels on 0th, 14th, 21th and 28th day. The treatment group that given combination extract of C. papaya 120mg/200g and M. citrifolia fruit 20mg/200g BW showed serum Alanine transaminase (ALT ), Aspartate transaminase (AST) and serum bilirubin level were diminished significantly.en_US
dc.language.isoenen_US
dc.publisherMuhammadiyah University Pressen_US
dc.subjectMorinda citrifoliaen_US
dc.subjectCarica papayaen_US
dc.subjecttransaminaseen_US
dc.subjectbilirubinen_US
dc.subjectantituberculosisen_US
dc.titleThe Combined Effect of An Extracts of Morinda citrifolia L. Fruits and Carica papaya L. Leaves of Serum Transaminase and Bilirubin in Antituberculosis–induced Ratsen_US
dc.typeArticleen_US


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