Antibacterial Activity of Pawpaw (Carica papaya) against Multidrugresistant Staphylococcus aureus and Multidrug-Resistant Escherichia Coli

Abstract

This study was designed to evaluate in vitro antibacterial activity of several part of pawpaw (Carica papaya) against multidrug-resistant bacteria. Leaves, stems, and roots were extracted with ethanol and tested for in vitro antibacterial activity using agar dilution method against multidrug-resistant Staphylococcus aureus and multidrug-resistant Escherichia coli. Stems extracts show highest antibacterial activity against the test bacteria with minimum inhibitory concentration (MIC) value of 30 mg/mL for both bacteria. Leaves and roots extract have antibacterial activity against multidrugresistant

Staphylococcus aureus with MIC values of 70 and 50 mg/mL, respectively. The MIC values of leaves and roots extract on multidrug-resistant Escherichia coli were 80 and 70 mg/mL, respectively. Several phytochemicals in the extracts are responsible for the antibacterial activity.