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Antibacterial Activity of Pawpaw (Carica papaya) against Multidrugresistant Staphylococcus aureus and Multidrug-Resistant Escherichia Coli

dc.contributor.authorYuliani, Ratna
dc.contributor.authorIndrayudha, Peni
dc.contributor.authorSetyawan, Wahyu
dc.contributor.authorSoranta, Eko Wahyu
dc.contributor.authorHaptiasari, Eriana
dc.date.accessioned2015-03-03T08:00:17Z
dc.date.available2015-03-03T08:00:17Z
dc.date.issued2012-11
dc.identifier.citationAyoola, G.A., Coker, H.A.B., Adesegun, S.A., Adepoju-Bello, A.A., Obaweya, A., Ezennia, E.C., Atangbayila, T.O., 2008, Phytochemical screening and antioxidant activities of some selected medicinal plants used for malaria therapy in southwestern Nigeria, Tropical Journal of Pharmaceutical Research, 7 (3), 1019-1024. Cheeke, P.R., 1999, Actual and potential applications of Yucca schidigera and Quillaja saponaria saponins in human and animal nutrition, Proceedings of the American Society of Animal Science, 1-10. Cowan, M.M., 1999, Plant products as antimicrobial agents, Clinical Microbiology Reviews, 12 (4), 564–582 Doughari, J. H., Elmahmood, A. M. and Manzara, S., 2007, Studies on the antibacterial activity of root extracts of Carica papaya L., African Journal of Microbiology Research, 037-041. Doughari, J. H., Elmahmood, A. M., and Manzara, S., 2007, Studies on the antibacterial activity of root extracts of Carica papaya L., African Journal of Microbiology Research, 037-041. Fattorusso, E. and Taglialatela-Scafati, O., 2008, Modern alkaloids, Wiley-VCH Verlag GmbH & Co. KGaA. Gomez-Flores, R., Arzate-Quintana, C., Quintanilla-Licea, R., Tamez-Guerra, P., Tamez-Guerra, R., Monreal-Cuevas, R., and Rodríguez-Padilla, R., 2008, Antimicrobial activity of Persea americana Mill (Lauraceae) (Avocado) and Gymnosperma glutinosum (Spreng.) Less (Asteraceae) leaf extracts and active fractions against Mycobacterium tuberculosis, AmericanEurasian Journal of Scientific Research, 3 (2), 188-194. Gould, I.M., 2009, Antibiotic resistance: the perfect storm, International Journal of Antimicrobial Agents, 34, S2-S5. Khan, J.A., Yadav, J., Srivastava, Y. and Pal, P.K., 2012, In vitro evaluation of antimicrobial properties of Carica papaya, International Journal of Biology, Pharmacy, and Allied Sciences, 1 (7), 933-945 Krishna, K.L., Paridhavi, M., Patel, J.A., 2008, Review on nutritional, medicinal and pharmacological properties of papaya (Carica papaya Linn), Natural Product Radiance, 7 (4), 364-373. Njoku, O.V. and Obi, C., 2009, Phytochemical constituents of some selected medicinal plants, African Journal of Pure and Applied Chemistry, 3 (11), 228-233. Rahman, S., Imran, M., Muhammad, N., Hassan, N., Chisthi, A. K., Khan, A. F., Sadozai, K. S., and Khan, S. M., 2011, Antibacterial screening of leaves and stem of Carica papaya, Journal of Medicinal Plants Research, 5(20), 5167-5171. Spellberg, B., Guidos, R., Gilbert, D., Bradley, J., Boucher, H.W., Scheld, W. M., Bartlett, J. G., and Edwards, J.., 2008, The epidemic of antibiotic-resistant infections: a call to action for the medical community from the infectious diseases society of america, Clinical Infectious Diseases, 46, 155–64. Srivastava, N., Bhagyawant, S.S., and Sharma, V., 2010, Phytochemical investigation and antimicrobial activity of the endocarp of unripe fruit of Carica papaya, Journal of Pharmacy Research, 3 (12),3132-3134. Taiwo, S.S., 2011, Antibiotic-resistant bugs in the 21st century: A public health challenge, World Journal of Clinical Infectious Diseases, 30, 1(1), 11-16. Yusha’u, M., Onuorah, F. C., and Murtala, Y., 2009, In-vitro sensitivity pattern of some urinary tract isolates to Carica papaya extracts, Bayero Journal of Pure and Applied Sciences, 2(2), 75-78.en_US
dc.identifier.urihttp://hdl.handle.net/11617/5302
dc.description.abstractThis study was designed to evaluate in vitro antibacterial activity of several part of pawpaw (Carica papaya) against multidrug-resistant bacteria. Leaves, stems, and roots were extracted with ethanol and tested for in vitro antibacterial activity using agar dilution method against multidrug-resistant Staphylococcus aureus and multidrug-resistant Escherichia coli. Stems extracts show highest antibacterial activity against the test bacteria with minimum inhibitory concentration (MIC) value of 30 mg/mL for both bacteria. Leaves and roots extract have antibacterial activity against multidrugresistant Staphylococcus aureus with MIC values of 70 and 50 mg/mL, respectively. The MIC values of leaves and roots extract on multidrug-resistant Escherichia coli were 80 and 70 mg/mL, respectively. Several phytochemicals in the extracts are responsible for the antibacterial activity.en_US
dc.publisherUniversitas Muhammadiyah Surakartaen_US
dc.subjectAntibacterialen_US
dc.subjectCarica papayaen_US
dc.subjectEscherichia colien_US
dc.subjectStaphylococcus aureusen_US
dc.subjectmultidrugresistanten_US
dc.titleAntibacterial Activity of Pawpaw (Carica papaya) against Multidrugresistant Staphylococcus aureus and Multidrug-Resistant Escherichia Colien_US
dc.typeArticleen_US


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