Potential Activity of Rambutan (Nepheliumlappaceum L.) Fruit Peel Extract as Antidiabetic and Antihypercholesterolemia

Abstract

Rambutan (Nephelium lappaceum L.) fruit peel extract had been reported to have very strong antioxidant activity and had more with flavonoids and phenolic compounds. This study aims to determine the potential antidiabetic and antihypercholesterolemia activities of Rambutan fruit peel ethanol extract in vivo. This research design was pre and postcontrol group, 25 mice were divided into 5 groups. Group I (negative control) were given a solution of 0.5% CMC-Na, group II (positive control antidiabetic) was given Glibenclamide 0.45 mg/kg, III, IV, and V were given ethanol extract of rambutan peel with successive doses of 500, 250, and 125 mg/kgBW. While the antihypercholesterolemic testing, in group II given Cholesteramine 0.8 g/kg, whereas group III, IV and V given ethanol extract of rambutan skin with a dose of 500, 250, and 125 mg/kgBW, respectively. Treatment of mice conducted for 2 weeks. The results showed that the ethanol extract of Rambutan fruit peel with dose of 125, 250, and 500 mg/kgBW had blood glucose lowering activity in mice induced alloxan, the percentage decrease in blood glucose levels at 22.65 ± 2.10%, 49.05 ± 3.22%, 61.76 ± 4.26%. While the antihypercholesterolemia activity of the ethanol extract of Rambutan peel with dose of 125, 250, and 500 mg/kgBW had an activity to lower cholesterol levels 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8.26%, respectively.