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Potential Activity of Rambutan (Nepheliumlappaceum L.) Fruit Peel Extract as Antidiabetic and Antihypercholesterolemia

dc.contributor.authorSuhendi, Andi
dc.contributor.authorMuhtadi
dc.date.accessioned2015-11-05T07:09:52Z
dc.date.available2015-11-05T07:09:52Z
dc.date.issued2015-10-15
dc.identifier.citation[1] PERKENI., Konsensus Pengendalian dan Pencegahan Diabetes MelitusTipe 2 di Indonesia, Jakarta, 2011. [2] Ratnawati, H. &Wahyu, W., Anticholesterol Activity of Velvet Bean (MucunapruriensL.) towards Hypercholesterolemic Rats, Sains Malaysiana, Vol. 40 (4) pp. 317–321, 2011 [3] Muhtadi, Haryoto, Sujono, T.A., Suhendi, A., and Yen, K.H., Antioxidant Activity and Chemical Constituents of Some Indonesian Fruit Peels, Medicinal Plant, 6(1), 43-46, 2014. [4] Krentz, A. J., and Bailey, C. J., Oral Diabetic Agents Current Role in Type 2 Diabetes Melitus, Riview Article, 65 (3), 394, 398, 403, 2015. [5] Lin, J.,S., An Alternative Treatment Of Hyperlipidemia WithRed Yeast Rice: A Case Report, Journal of Medical Case Reports, 4(4), 2010. [6] Kumar, E. K., Ramesh, A., and Kasiviswanath, R., Hypoglicemic and Antihyperglicemic Effect of Gmelinaasiatica Linn. in Normal and in Alloxan Induced Diabetic Rats, India, Department of Pharmaceutical Sciences Ardha Pradesh, 2005. [7] Roongpisuthipong, C., S. Banphotkasem, S. Komindr and V. Tanphaichitr., Postprandial Glucose and Insulin Responses to Various Tropical Fruits of Equivalent Carbohydrate Content in non-insulindependent Diabetes Melitus, Diabetes Research and Clinical Practice Vol. 14, pp. 123-131, 1991. [8] Manaharan, T., Palanisamy, U. D., and Ming, C. H., Tropical Plant Extracts as Potential Antihyperglycemic Agents, Article 17, pp. 5915- 5923, 2012. [9] Batubara, R. W., Uji Aktivitas Antioksidan Ekstrak Etanol Kulit Buah Durian (DuriozibethinusMurr) Lokal dan Fraksi-Fraksinya Dengan Metode DPPH Serta Penetapan Kadar Fenolikdan Flavonoid Totalnya, Skripsi, Surakarta, Fakultas Farmasi Universitas Muhammadiyah Surakarta, 2011. [10] Haruenkeit, R., Poovarodom, S., Vearasilp, S., et al., Comparison of Bioactive Compounds, Antioxidant and Antiproliferative Activities of Mon Thong Durian During Ripening, Food Chemistry, 118, 540-547, 2010. [11] Leontowicz, H., Maria, L., Iwona, J., et al., Positive Effects of Durian Fruit At DifferentStages of Longan (Dimocarpus longan) Ripening On The Hearts and Livers of Rats Fed Diets High in Cholesterol, European Journal of Integrative Medicine, vol. 3, pp. 169-181, 2011. [12] Dalimartha, S., Atlas Tumbuhan Obat Indonesia, Jilid 2, Jakarta, Puspa Swara, 2003. [13] Palanisamy, U. D., Ling, L. T., Manaharan T., Appleton, D., Rapid Isolation of Geraniin From Nepheliumlappaceum Rind Waste and it’s Anti-Hyperglycemic activity, Food Chemistry Vol. 127, pp. 21–27, 2011 [14] Waltner-Law M, E., Wang X, L., Law B, K., Hall R, K., Nawano, M.,, Epigallocatechingallate, a constituent of Green tea represses hepatic glucose production, Journal, Vol. 277 (38) pp. 34933–34940, 2002 [15] Tabata, H., Katsube, T., Tsuma, T., Ohta, Y.,,Imawaka, N., danUtsumi, T., Isolation and evaluation of the radical-scavenging activity of the antioxidants in the leaves of an edible plant Mallotusjaponicus, Food Chemistry, Vol. 109 (1) pp. 64-71, 2008. [16] Tamimy., Aktivitas Antioksidan Ekstrak Etanol Kulit Buah Rambutan (Nephelliumlappaceum L.) Terhadap Peredaman Radikal Bebas DPPH Secara Spektrofotometri, Yogyakarta, SinarTampak, 2006 [17] Setiawan, B., danSuhartono, E.,, Stres Oksidatif dan Peran Antioksidan pada Diabetes Melitus, Maj Kedokt Indon, Volume 55 (2) pp. 86-91, 2005. [18] Sujono, T. A., danSutrisna, EM., Pengaruh Lama Praperlakuan Flavonoid Rutin terhadap Efek Hipoglikemik Tolbutamid pada Tikus Jantan yang Diinduksi Aloksan, Jurnal Penelitian Sains dan Teknologi, Vol. 11 (2) pp. 94, 97, 2010. [19] Widowati, W., Potensi Antioksi dan sebagai Antidiabetes, Jurnal JKM, Vol 7 (2) pp. 2,3,5-7, 2008. [20] Sanjaya, A., Pembuatan Serbuk Pewarna Makanan Dari Ekstrak Daun Suji (Pleomeleangsutifolia) Secara Ekstraksi Soxhlet dan Ekstraksi Maserasi (Online), 2012. (http://lib.unnes.ac.id/12466, diaksestanggal23 Desember 2013) [21] Dheer, R., and Bhatnagar, P., A study of the Antidiabetic Activity of Barleriaprionitis Linn., Indian Journal of Pharmacology, Vol. 42 (2), pp. 70-3, 2010. [22] Lee, Soo-Kyung, Hwang, Ji-Yeon, et al., Inhibitory Activity of Euonymus alatus against alpha-glucocidase, In Vitro and In Vivo, Nutrition Research and Practice, pp. 184-188, 2007.in_ID
dc.identifier.issn2470-4330
dc.identifier.urihttp://hdl.handle.net/11617/6270
dc.description.abstractRambutan (Nephelium lappaceum L.) fruit peel extract had been reported to have very strong antioxidant activity and had more with flavonoids and phenolic compounds. This study aims to determine the potential antidiabetic and antihypercholesterolemia activities of Rambutan fruit peel ethanol extract in vivo. This research design was pre and postcontrol group, 25 mice were divided into 5 groups. Group I (negative control) were given a solution of 0.5% CMC-Na, group II (positive control antidiabetic) was given Glibenclamide 0.45 mg/kg, III, IV, and V were given ethanol extract of rambutan peel with successive doses of 500, 250, and 125 mg/kgBW. While the antihypercholesterolemic testing, in group II given Cholesteramine 0.8 g/kg, whereas group III, IV and V given ethanol extract of rambutan skin with a dose of 500, 250, and 125 mg/kgBW, respectively. Treatment of mice conducted for 2 weeks. The results showed that the ethanol extract of Rambutan fruit peel with dose of 125, 250, and 500 mg/kgBW had blood glucose lowering activity in mice induced alloxan, the percentage decrease in blood glucose levels at 22.65 ± 2.10%, 49.05 ± 3.22%, 61.76 ± 4.26%. While the antihypercholesterolemia activity of the ethanol extract of Rambutan peel with dose of 125, 250, and 500 mg/kgBW had an activity to lower cholesterol levels 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8.26%, respectively.in_ID
dc.language.isoenin_ID
dc.publisherUniversitas Muhammadiyah Surakartain_ID
dc.subjectAntihypercholesterolemiain_ID
dc.subjectantidiabeticin_ID
dc.subjectfruit peelin_ID
dc.subjectin vivoin_ID
dc.subjectrambutan (Nephelium lappaceum L.)in_ID
dc.titlePotential Activity of Rambutan (Nepheliumlappaceum L.) Fruit Peel Extract as Antidiabetic and Antihypercholesterolemiain_ID
dc.typeArticlein_ID


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