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dc.contributor.authorHaryoto, Haryoto
dc.contributor.authorNurhardianti, Noviana
dc.contributor.authorSujono, Tanti Azizah
dc.contributor.authorSuhendi, Andi
dc.contributor.authorMuhtadi, Muhtadi
dc.date.accessioned2016-02-24T07:47:27Z
dc.date.available2016-02-24T07:47:27Z
dc.date.issued2016-02
dc.identifier.citationAfjalus, S.M., Malik, S., Emrul, H., Sanjana, S., & Farjana, Y., 2013, Evaluation of Neuropharmacological, Antibacterial, and Antinociceptive Activity of Methanolic Extract of the Bark of Cinometra ramiflora Linn (Leguminoseae), Int. J. res. Ayurveda Pharm., Vol. 4 (2): 311- 319. Bunyapraphatsara, N., Jutiviboonsuk, A., Sornlek, P., Therathanathorn, W., Aksornkaew, S., Fong, Hari. H.S., et al., 2003, Pharmacological studies of plants in the mangrove, Thai Journal of Phytopharmacy, Vol. 10 (2): 1-12. Bhushan, M.S., Rao, C.V., Ojha, S.K., Vijayakumar, M., & Verma, A., 2010, An Analytical Review of Plants for Antidiabetic Activity with Their Phytoconstituen & Mechanism of Action, International Journal of Pharmaceutical Sciences of Research, Vol. 1 (1): 29-46. Corwin, E.J., 2000, Handbook of Pathophysiology, 2 nd ed., New York, Lippincott. Diasys Diagnostic System Gmbh, 2009, Glucose GOD FS, Germany, Diasys Diagnostic System Gmbh. Johnson-Delaney, C., 1996, Exotic Animal Companion Medicine Handbook for Vaterinarians, Zoological Education Network. Khan, M.A., 2006. Phytochemical and pharmacological screening of Shingra (Cynometra ramiflora Linn., Family: Leguminosae) bark based on its traditional uses. Department of Pharmacy Southern University, 1-4. Lenzen, S., 2007, The mechanisms of alloxan-and streptozotocin-induced diabetes, In: Diabetologia, Vol. 51(2): 120- 138. Malangngi, L.P., Sangi, M.S., & Paendong, J. E., 2012, Penentuan Kandungan Tanin dan Uji Aktivitas Antioksidan Ekstrak Biji Buah Alpukat (Persea americana Mill.), Jurnal Mipa Unsrat Online, Vol. 1 (1): 5-10. Monica, F., 2006, Pengaruh pemberian air seduhan Serbuk biji alpukat (persea Americana mill.) Terhadap Kadar glukosa darah tikus wistar Yang diberi beban glukosa, Karya Tulis Ilmiah, Fakultas Kedokteran, Universitas Diponegoro. Mycek, M.J., Harvey, R.A. & Champe, C.C., 2001, Insulin dan Obat-obat Hipoglikemik Oral, Edisi 2, diterjemahkan oleh Azwar Agoes, Jakarta, Widya Medika. Nugroho, A.E., 2006, Hewan Percobaan Diabetes Mellitus : Patologi dan Mekanisme Aksi Diabetogenik, Biodiversitas, Vol.7 (4): 1-9. Sari, D.P., 2013, Aktivitas Antibakteri Ekstrak Etanol Kulit Batang Tumbuhan Sala terhadap S. aureus, E.coli dan Klebsiella p., Skripsi, Fakultas farmasi, Universitas Muhammadiyah Surakarta. Sujono, T.A., & Munawaroh, R., 2009, Antaraksi Quercetin dengan Tolbutamid: Kajian Terhadap Perubahan Kadar Glukosa Darah pada Tikus Jantan yang Diinduksi Aloksan, Jurnal Penelitian Sains & Teknologi, Vol.10 (2): 121-129. Szkudelski, T., 2001, The Mechanism of Alloxan and Streptozotocin Action in β Cells of the Rats Pancreas, Phystol. Res. 50. Tajudin, T.S.A., Mat, N., Siti-Aishah,A.B., Yusran, A.M., Alwi, A., & Ali, A.M., 2012, Cytotoxicity, Antiproliferative Effects, and Apoptosis Inductions of Methanolic Extract of Cynometra cauliflora L. Whole Fruit on Human Promyelocytic Leukemia HL-60 Cells, Evidence. Based Complementary and Alternative Medicine, Vol. 2012: 1-6. Tiwari, P., Rahuja, N., Kumar, R., Lakshmi, V., Srivastava, M.N., Agarwal, S.C., et al., 2008, Search for Antihyperglicemic activity in few marine flora and fauna, Indian Journal of Science and Technology, Vol. 1 (5): 187-212. (Oct. 2008), http://www.indjst.org. Walde, S.S., Dohle, C., Schott-Ohly, P., & Gleichmann, H., 2002, Molecular target structures in alloxan-induced diabetes in mice, Life Sciences, Vol. 71 (14): 1681- 1694. Watkins, D., Cooperstein, S.J., & Lazarow, A., 1963, Effect of Alloxan on Permeability of Pancreatic Islet Tissue In Vitro, American Journal of Physiology, Vol. 207 (2): 436- 440. Widowati, W., 2008, Potensi Antioksidan sebagai Antidiabetes, Jkm, Vol. 7 (2): 1-11. Diasys Diagnostic System Gmbh, 2009, Glucose GOD FS, Germany, Diasys Diagnostic System Gmbh. Johnson-Delaney, C., 1996, Exotic Animal Companion Medicine Handbook for Vaterinarians, Zoological Education Network. Khan, M.A., 2006. Phytochemical and pharmacological screening of Shingra (Cynometra ramiflora Linn., Family: Leguminosae) bark based on its traditional uses. Department of Pharmacy Southern University, 1-4. Lenzen, S., 2007, The mechanisms of alloxan-and streptozotocin-induced diabetes, In: Diabetologia, Vol. 51(2): 120- 138. Malangngi, L.P., Sangi, M.S., & Paendong, J. E., 2012, Penentuan Kandungan Tanin dan Uji Aktivitas Antioksidan Ekstrak Biji Buah Alpukat (Persea americana Mill.), Jurnal Mipa Unsrat Online, Vol. 1 (1): 5-10. Monica, F., 2006, Pengaruh pemberian air seduhan Serbuk biji alpukat (persea Americana mill.) Terhadap Kadar glukosa darah tikus wistar Yang diberi beban glukosa, Karya Tulis Ilmiah, Fakultas Kedokteran, Universitas Diponegoro. Mycek, M.J., Harvey, R.A. & Champe, C.C., 2001, Insulin dan Obat-obat Hipoglikemik Oral, Edisi 2, diterjemahkan oleh Azwar Agoes, Jakarta, Widya Medika. Nugroho, A.E., 2006, Hewan Percobaan Diabetes Mellitus : Patologi dan Mekanisme Aksi Diabetogenik, Biodiversitas, Vol.7 (4): 1-9. Sari, D.P., 2013, Aktivitas Antibakteri Ekstrak Etanol Kulit Batang Tumbuhan Sala terhadap S. aureus, E.coli dan Klebsiella p., Skripsi, Fakultas farmasi, Universitas Muhammadiyah Surakarta. Sujono, T.A., & Munawaroh, R., 2009, Antaraksi Quercetin dengan Tolbutamid: Kajian Terhadap Perubahan Kadar Glukosa Darah pada Tikus Jantan yang Diinduksi Aloksan, Jurnal Penelitian Sains & Teknologi, Vol.10 (2): 121-129. Szkudelski, T., 2001, The Mechanism of Alloxan and Streptozotocin Action in β Cells of the Rats Pancreas, Phystol. Res. 50. Tajudin, T.S.A., Mat, N., Siti-Aishah,A.B., Yusran, A.M., Alwi, A., & Ali, A.M., 2012, Cytotoxicity, Antiproliferative Effects, and Apoptosis Inductions of Methanolic Extract of Cynometra cauliflora L. Whole Fruit on Human Promyelocytic Leukemia HL-60 Cells, Evidence. Based Complementary and Alternative Medicine, Vol. 2012: 1-6. Tiwari, P., Rahuja, N., Kumar, R., Lakshmi, V., Srivastava, M.N., Agarwal, S.C., et al., 2008, Search for Antihyperglicemic activity in few marine flora and fauna, Indian Journal of Science and Technology, Vol. 1 (5): 187-212. (Oct. 2008), http://www.indjst.org. Walde, S.S., Dohle, C., Schott-Ohly, P., & Gleichmann, H., 2002, Molecular target structures in alloxan-induced diabetes in mice, Life Sciences, Vol. 71 (14): 1681- 1694 Watkins, D., Cooperstein, S.J., & Lazarow, A., 1963, Effect of Alloxan on Permeability of Pancreatic Islet Tissue In Vitro, American Journal of Physiology, Vol. 207 (2): 436- 440. Widowati, W., 2008, Potensi Antioksidan sebagai Antidiabetes, Jkm, Vol. 7 (2): 1-11in_ID
dc.identifier.issn2407-9189
dc.identifier.urihttp://hdl.handle.net/11617/6721
dc.description.abstractSala (Cynometra ramiflora L.) is a mangrove plant that can be used as a traditional medicine. The stem bark of sala plant is part of the plant which useful for lowering blood of glucose levels. This research aims to determine the effects of antidiabetic ethanol extract of the bark Sala (Cynometra ramiflora L.) on blood of glucose levels wistar strain male rats induced alloxan 150 mg/kgBW. Twenty five male Wistar rats were divided into 5 groups, such as the negative control group were given a suspension of 0.5% CMC-Na, the positive control group were given suspensions glibenclamide 0.9 mg/kgBW, and three groups were treated of the Sala stem bark dose 125 mg/kgBW, 250 mg/kgBW, and 500/kgBW. The administration was done every day for 11 days with oral administration of 2.5 ml/200gBW after increase the volume in blood glucose ≥ 200 mg/dL in rats induced alloxan 150 mg/kgBW. The data obtained from the examination of blood glucose on day 0, the 3rd and 11th day after treatment. Statistical test results P value <0.05 showed that the ethanol extract of the Sala stem bark in dose 125 m /kgBW, 250 mg kgBW and 500 mg/kgBW can decrease blood glucose in rats and has significant difference than negative control.in_ID
dc.language.isoidin_ID
dc.publisherLPPM STIKES Muhammadiyah Kudusin_ID
dc.subjectEthanol extractin_ID
dc.subjectbarkin_ID
dc.subjectSala plantin_ID
dc.subjectblood of glucose levelsin_ID
dc.subjectalloxanin_ID
dc.titleAntidiabetes Mellitus Ekstrak Etanol Kulit Batang Tumbuhan Sala (Cynometra Ramiflora L.) Terhadap Tikus Jantan Galur Wistar yang Diinduksi Aloksanin_ID
dc.typeArticlein_ID


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