Effect of Ca2+ to Salicylic Acid Release in Pectin Based Controlled Drug Delivery System

Abstract

Wastes from orange peel are potentially be utilized to produce pectin, which is currently an import commodity. Pectin can be used in making edible film. Edible films are potentially used as a drug delivery system membrane after a tooth extraction. Drug that used in the drug delivery system is salicylic acid. It is an antiseptic. In order to control the drug release rate, crosslinking process is added in the manufacturing of membrane with CaCl2.2H2O as crosslinker. Pectin was diluted in water and mixed with a plasticizer and CaCl2.2H2O solution at 66°C to make edible film. Then the mixture was dried in an oven at 50 °C. After edible film was formed, it was coated using plasticizer and CaCl2.2H2O solution with various concentration 0, 0.015, 0.03 and 0.05 g/mL. This study show that the more concentration of crosslinker added, the slower release of salicylic acid would be.This was indicated by the value of diffusivites were getting smaller respectively. The addition of crosslinker also caused smaller gels swelling value, which makes the membrane mechanically stronger.