dc.contributor.author	Wikantyasning, Erindyah R
dc.contributor.author	Da’i, Muhammad
dc.contributor.author	Wahyuningtyas, Nurcahyanti
dc.date.accessioned	2015-04-13T04:33:16Z
dc.date.available	2015-04-13T04:33:16Z
dc.date.issued	2014
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Antihyperglycaemic And Anti-Oxidant Properties Of Andrographis Paniculata In Normal And Diabetic Rats. Clinical And Experimental Pharmacology And Physiology, 27, 358-363.	in_ID
dc.identifier.uri	http://hdl.handle.net/11617/5630
dc.description.abstract	Penelitian sebelumnya terhadap ekstrak meniran dan sambiloto menunjukkan aktivitas antidiabetes dan antioksidan. Nanoteknologi dapat digunakan untuk mengembangkan formulasi obat tradisional, berkaitan dengan berbagai keterbatasan sediaan farmasi dari ekstrak herbal, antara lain dosis yang besar, kelarutan yang kecil dan rendahnya bioavailabilitas zat aktif. Penelitian ini dilakukan untuk mengembangkan obat herbal terstandar, dengan memformulasi ekstrak herba sambiloto dan meniran menjadi sediaan nanoemulsi, untuk kemudian diuji aktivitas antidiabetik dan aktivitas antioksidannya, dibandingkan dengan sediaan ekstrak. Formulasi sediaan nanoemulsi dilakukan dengan metode ultrasonikasi dengan berbagai emulgator seperti Tween 80, Span dan kombinasinya. Sediaan nanoemulsi selanjutnya dienkapsulasi dengan minyak zaitun dan dilakukan optimasi nanoenkapsulasi. Nanoemulsi yang terbentuk dan stabilitas fisiknya dikarakterisasi dengan alat zetasizer. Selanjutnya dilakukan standarisasi ekstrak dalam sediaan nanoemulsi dengan metode HPLC. Hasil percobaan menunjukkan formulasi SNEDDS dengan surfaktan tween menghasilkan larutan yang stabil, dan selanjutnya pembentukan self assembled nanoemulsi dapat dilakukan dengan formulasi tersebut.	in_ID
dc.language.iso	id	in_ID
dc.publisher	Universitas Muhammadiyah Surakarta	in_ID
dc.subject	obat herbal terstandar	in_ID
dc.subject	antidiabetik	in_ID
dc.subject	meniran	in_ID
dc.subject	sambiloto	in_ID
dc.subject	nanoemulsi	in_ID
dc.title	Formulasi Obat Herbal Terstandar Kombinasi Ekstrak Sambiloto (Andrographis Paniculata (Burm F.) Ness.) Dan Meniran (Phyllanthus Niruri, L.) Sebagai Antidiabetes Dengan Aplikasi Nanoteknologi	in_ID
dc.type	Technical Report	in_ID

Formulasi Obat Herbal Terstandar Kombinasi Ekstrak Sambiloto (Andrographis Paniculata (Burm F.) Ness.) Dan Meniran (Phyllanthus Niruri, L.) Sebagai Antidiabetes Dengan Aplikasi Nanoteknologi

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